气候变化领域集成服务门户(CCPortal): Long-term exposure to ambient air pollution is associated with elevated low- density lipoprotein cholesterol level

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DOI	10.1016/j.atmosenv.2020.117970
	Long-term exposure to ambient air pollution is associated with elevated low- density lipoprotein cholesterol level
	Hehua Z.; Yuhong Z.
发表日期	2021
ISSN	1352-2310
卷号	244
英文摘要	Low-density lipoprotein cholesterol (LDL-C) is an important indicator to assess atherosclerosis risk, and air pollution might increase the risk of cardiovascular disease by elevating the LDL-C level. To date, there is no consensus about the associations between exposures to different air pollutants and LDL-C status. In this study, we explored the associations between long-term air pollution exposure and LDL-C status based on a cohort in Northeast China. We found that long-term air pollutant exposure (measured in 10-μg/m3 increments) to PM2.5 (odds ratio [OR] = 2.16, 95% confidence interval [CI]: 1.53–3.04), PM10 (OR = 1.39, 95% CI: 1.12–1.72), SO2 (OR = 1.54, 95% CI: 1.28–1.86), NO2 (OR = 1.44, 95% CI: 1.23–1.67), and CO (OR = 1.02, 95% CI: 101–1.03) were positively associated with elevated LDL-C level. Of all pollutants, PM2.5 had the largest effect on LDL-C level. Increased O3 exposure (OR = 0.66, 95% CI: 0.57–0.76) had a beneficial effect on LDL-C level. Interaction effects of air pollution and physical activity, as well as white blood cell counts, on LDL-C level were found. Effects of air pollution on triglycerides and high-density lipoprotein cholesterol were not significant, and effects of air pollution on total cholesterol were weaker than those on LDL-C. This study provides evidence for the effect of air pollution on LDL-C level, as well as the prevention of atherosclerosis risk. © 2020 Elsevier Ltd
关键词	Air pollution Atherosclerosis Inflammation Low-density lipoprotein Physical activity
语种	英语
scopus关键词	Blood; Cholesterol; Diseases; Lipoproteins; Risk assessment; Sulfur dioxide; Air pollution exposures; Ambient air pollution; Cardio-vascular disease; Confidence interval; High-density lipoprotein cholesterols; Interaction effect; Long term exposure; Low density lipoproteins; Air pollution; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; ambient air; atmospheric pollution; blood; cardiovascular disease; chemical compound; health risk; mortality risk; pollution exposure; protein; risk factor; spatiotemporal analysis; adult; aged; air pollution; ambient air; Article; cardiovascular disease; cardiovascular risk; China; cholesterol blood level; clinical assessment; cohort analysis; disease association; environmental exposure; evidence based practice; female; human; hyperlipidemia; leukocyte count; long term exposure; low density lipoprotein cholesterol level; major clinical study; male; outcome assessment; particulate matter 2.5; physical activity; priority journal; prospective study; risk assessment; risk factor; China
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248820
作者单位	Clinical Research Center, Shengjing Hospital of China Medical University, Huaxiang Road No. 39, Tiexi District, China; Department of Clinical Epidemiology, Shenjing Hospital of China Medical University, Sanhao Street, No. 36, Heping District, China
推荐引用方式 GB/T 7714	Hehua Z.,Yuhong Z.. Long-term exposure to ambient air pollution is associated with elevated low- density lipoprotein cholesterol level[J],2021,244.
APA	Hehua Z.,&Yuhong Z..(2021).Long-term exposure to ambient air pollution is associated with elevated low- density lipoprotein cholesterol level.ATMOSPHERIC ENVIRONMENT,244.
MLA	Hehua Z.,et al."Long-term exposure to ambient air pollution is associated with elevated low- density lipoprotein cholesterol level".ATMOSPHERIC ENVIRONMENT 244(2021).