气候变化领域集成服务门户(CCPortal): Differential inflammatory potential of particulate matter (PM) size fractions from imperial valley, CA

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DOI	10.1016/j.atmosenv.2020.117992
	Differential inflammatory potential of particulate matter (PM) size fractions from imperial valley, CA
	D'Evelyn S.M.; Vogel C.F.A.; Bein K.J.; Lara B.; Laing E.A.; Abarca R.A.; Zhang Q.; Li L.; Li J.; Nguyen T.B.; Pinkerton K.E.
发表日期	2021
ISSN	1352-2310
卷号	244
英文摘要	Particulate matter (PM) in Imperial Valley originates from a variety of sources such as agriculture, traffic at the border crossing, emissions from the cross-border city of Mexicali, and the drying lakebed of the Salton Sea. Dust storms in Imperial Valley, California regularly lead to exceedances of the federal air quality standards for PM10 (diameter less than 10 μm). To determine if there are differences in the composition and biological response to Imperial County PM by size, ambient PM samples were collected from a sampling unit stationed in the northern-most part of the valley, South of the Salton Sea. Ultrafine, fine, and coarse PM samples were collected and extracted separately. Chemical composition of each size fraction was obtained after extraction by using several analytical techniques, and biological response was measured by exposing a cell line of macrophages to particles and quantifying subsequent gene expression. Biological measurements demonstrated coarse PM induced an inflammatory response in macrophages measured in increases of inflammatory markers IL-1ß, IL-6, IL-8 and CXCL2 expression, whereas ultrafine and fine PM only demonstrated significant increases in expression of CYP1a1. These differential responses were due not only to particle size, but to the distinct chemical profiles of each size faction as well. Community groups in Imperial Valley have already completed several projects to learn more about local air quality, giving residents access to data that provides real-time levels of PM2.5 and PM10 as well as recommendations on health-based practices dependent on the current AQI (air quality index). However, to date there is no information on the composition or toxicity of ambient PM from the region. The data presented here could provide more definitive information on the toxicity of PM by size, and further inform the community on local air quality. © 2020 Elsevier Ltd
关键词	Bioaerosols Coarse PM Endotoxin Imperial valley Particulate matter Size fraction
语种	英语
scopus关键词	Agricultural robots; Air quality; Cell culture; Chemical analysis; Gene expression; Landforms; Macrophages; Particle size; Particles (particulate matter); Storms; Toxicity; Air quality indices; Biological measurement; Biological response; Chemical compositions; Chemical profiles; Differential response; Inflammatory response; Particulate Matter; Air quality standards; anion; aromatic hydrocarbon receptor; beta glucan; CXCL2 chemokine; cytochrome P450 1A1; endotoxin; interleukin 1beta; interleukin 6; interleukin 8; polycyclic aromatic hydrocarbon; trace metal; air quality; air sampling; ambient air; particle size; particulate matter; air quality; analytic method; Article; California; chemical composition; community; controlled study; dust storm; elemental analysis; extraction; gene expression level; human; human cell; in vitro study; inductively coupled plasma mass spectrometry; inflammation; limit of detection; macrophage cell line; microflow imaging; microscopy; nonhuman; particle size; particulate matter; particulate matter 10; particulate matter 2.5; priority journal; real time reverse transcription polymerase chain reaction; time of flight mass spectrometry; toxicity testing; ultrafine particulate matter; wind speed; Baja California [(STT) Mexico]; California; Imperial County; Imperial Valley; Mexicali; Mexico [North America]; Salton Sea; United States
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248796
作者单位	Center for Health and the Environment, University of California, Davis, United States; Department of Environmental Toxicology, University of California, Davis, United States; KBI Biopharma, Inc., Boulder, CO, United States
推荐引用方式 GB/T 7714	D'Evelyn S.M.,Vogel C.F.A.,Bein K.J.,et al. Differential inflammatory potential of particulate matter (PM) size fractions from imperial valley, CA[J],2021,244.
APA	D'Evelyn S.M..,Vogel C.F.A..,Bein K.J..,Lara B..,Laing E.A..,...&Pinkerton K.E..(2021).Differential inflammatory potential of particulate matter (PM) size fractions from imperial valley, CA.ATMOSPHERIC ENVIRONMENT,244.
MLA	D'Evelyn S.M.,et al."Differential inflammatory potential of particulate matter (PM) size fractions from imperial valley, CA".ATMOSPHERIC ENVIRONMENT 244(2021).