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DOI	10.1126/science.7541554
	Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation
	Zúñiga-Pflücker J.C.; Jiang D.; Lenardo M.J.
发表日期	1995
ISSN	0036-8075
起始页码	1906
结束页码	1909
卷号	268 期号:5219
英文摘要	CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor α (TNF-α) and interleukin-1α (IL-1α), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-α or IL-1α was necessary for further thymocyte maturation and CD4 +CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.
英文关键词	cd4 antigen; cd8 antigen; interleukin 1alpha; interleukin 2 receptor; t lymphocyte receptor; tumor necrosis factor alpha; animal cell; article; cell differentiation; cell lineage; controlled study; fetus; fetus development; mouse; nonhuman; precursor; priority journal; t lymphocyte; thymocyte; Animal; Cell Differentiation; Cells, Cultured; Hematopoietic Stem Cells; Interleukin-1; Interleukin-7; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Organ Culture; Proto-Oncogene Protein c-kit; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Receptors, Interleukin-2; Stromal Cells; Support, Non-U.S. Gov't; T-Lymphocyte Subsets; T-Lymphocytes; Thymus Gland; Tumor Necrosis Factor
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246193
作者单位	Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, United States; University of Toronto, Department of Immunology, Medical Sciences Building, Toronto, Ont. M5S 1A8, Canada
推荐引用方式 GB/T 7714	Zúñiga-Pflücker J.C.,Jiang D.,Lenardo M.J.. Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation[J],1995,268(5219).
APA	Zúñiga-Pflücker J.C.,Jiang D.,&Lenardo M.J..(1995).Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation.Science,268(5219).
MLA	Zúñiga-Pflücker J.C.,et al."Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation".Science 268.5219(1995).