气候变化领域集成服务门户(CCPortal): Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence

CCPortal

DOI	10.1126/science.aap8775
	Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence
	Zhao W.; Caro F.; Robins W.; Mekalanos J.J.
发表日期	2018
ISSN	0036-8075
起始页码	210
结束页码	213
卷号	359 期号:6372
英文摘要	The bacterial type VI secretion system (T6SS) is a nanomachine that delivers toxic effector proteins into target cells, killing them. In mice, we found that the Vibrio cholerae T6SS attacks members of the host commensal microbiota in vivo, facilitating the pathogen's colonization of the gut. This microbial antagonistic interaction drives measurable changes in the pathogenicity of V. cholerae through enhanced intestinal colonization, expression of bacterial virulence genes, and activation of host innate immune genes. Because ablation of mouse commensals by this enteric pathogen correlated with more severe diarrheal symptoms, we conclude that antagonism toward the gut microbiota could improve the fitness of V. cholerae as a pathogen by elevating its transmission to new susceptible hosts.
英文关键词	antagonism; bacterium; cell; colonization; diarrheal disease; digestive system; gene; gene expression; host-pathogen interaction; microbial activity; pathogen; pathogenicity; protein; secretion; symptom; virulence; animal experiment; Article; bacterial colonization; bacterial virulence; cholera; commensal; diarrhea; Escherichia coli; gene expression; genetic transcription; genome analysis; immune response; innate immunity; intestine flora; mouse; nonhuman; organismal interaction; priority journal; type IV secretion system; Vibrio cholerae; animal; antibiosis; gene expression regulation; genetics; growth, development and aging; immunology; intestine; intestine flora; metabolism; microbiology; mutation; pathogenicity; physiology; reproductive fitness; symbiosis; type VI secretion system; Vibrio cholerae; virulence; Bacteria (microorganisms); Mus; Vibrio cholerae; cytokine; Animals; Antibiosis; Cholera; Cytokines; Escherichia coli; Gastrointestinal Microbiome; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Genetic Fitness; Intestines; Mice; Mutation; Symbiosis; Transcription, Genetic; Type VI Secretion Systems; Vibrio cholerae; Virulence
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246168
作者单位	Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States
推荐引用方式 GB/T 7714	Zhao W.,Caro F.,Robins W.,et al. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence[J],2018,359(6372).
APA	Zhao W.,Caro F.,Robins W.,&Mekalanos J.J..(2018).Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence.Science,359(6372).
MLA	Zhao W.,et al."Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence".Science 359.6372(2018).