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| DOI | 10.1126/science.abh1645 |
| Mapping genomic and epigenomic evolution in cancer ecosystems | |
| Ushijima T.; Clark S.J.; Tan P. | |
| 发表日期 | 2021 |
| ISSN | 0036-8075 |
| 起始页码 | 1474 |
| 结束页码 | 1479 |
| 卷号 | 373期号:6562 |
| 英文摘要 | Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data integration in understanding the molecular evolution of malignant cell states across the cancer life cycle. The widespread presence of driver mutations and epigenetic alterations in normal-appearing tissues is prompting a reassessment of how cancer initiation is defined. In later-stage cancers, studying the roles of clonal selection, epigenomic adaptation, and persister cells in metastasis and therapy resistance is an emerging field. Finally, the importance of tumor ecosystems in driving cancer development is being unraveled by single-cell and spatial technologies at unprecedented resolution. Improving cancer risk assessment and accelerating therapeutic discovery for patients will require robust, comprehensive, and integrated temporal, spatial, and multilevel tumor atlases across the cancer life cycle. © 2021 American Association for the Advancement of Science. All rights reserved. |
| 英文关键词 | cancer; cell; molecular analysis; mortality; risk assessment; cancer cell; cancer growth; cancer risk; cancer staging; carcinogenesis; cell interaction; data integration; disease course; disease risk assessment; DNA methylation; epigenetics; evolutionary adaptation; gene mapping; gene mutation; genet (clone); genetic heterogeneity; human; malignant neoplasm; metastasis; molecular evolution; Review; single cell RNA seq; therapy resistance; tumor microenvironment; genetic epigenesis; genetics; mutation; neoplasm; pathology; precancer; tumor microenvironment; Carcinogenesis; Epigenesis, Genetic; Epigenome; Evolution, Molecular; Humans; Mutation; Neoplasm Metastasis; Neoplasms; Precancerous Conditions; Tumor Microenvironment |
| 语种 | 英语 |
| 来源期刊 | Science
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/245809 |
| 作者单位 | Division of Epigenomics, National Cancer Center Research Institute, Tokyo, 104-0045, Japan; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW 2010, Australia; Cancer and Stem Cell Biology, Duke-NUS Medical School Singapore, Singapore, 169857, Singapore; Epigenomic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore |
| 推荐引用方式 GB/T 7714 | Ushijima T.,Clark S.J.,Tan P.. Mapping genomic and epigenomic evolution in cancer ecosystems[J],2021,373(6562). |
| APA | Ushijima T.,Clark S.J.,&Tan P..(2021).Mapping genomic and epigenomic evolution in cancer ecosystems.Science,373(6562). |
| MLA | Ushijima T.,et al."Mapping genomic and epigenomic evolution in cancer ecosystems".Science 373.6562(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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