气候变化领域集成服务门户(CCPortal): Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia

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DOI	10.1126/science.aar8486
	Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia
	Tucci S.; Vohr S.H.; McCoy R.C.; Vernot B.; Robinson M.R.; Barbieri C.; Nelson B.J.; Fu W.; Purnomo G.A.; Sudoyo H.; Eichler E.E.; Barbujani G.; Visscher P.M.; Akey J.M.; Green R.E.
发表日期	2018
ISSN	0036-8075
起始页码	511
结束页码	516
卷号	361 期号:6401
英文摘要	Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores. © 2018 American Association for the Advancement of Science. All Rights Reserved.
英文关键词	acyl coenzyme A desaturase; adaptation; evolutionary theory; genome; historical record; hominid; human evolution; Neanderthal; polymorphism; allele; archeology; Article; copy number variation; evolutionary adaptation; fatty acid desaturation; gene cluster; gene flow; genetic variation; human; Indonesia; population research; population size; population structure; priority journal; pygmy; single nucleotide polymorphism; whole genome sequencing; adaptation; animal; body height; dwarfism; evolution; genetic selection; genetics; Homo neanderthalensis; human genome; island (geological); population; East Nusa Tenggara; Flores [Lesser Sunda Islands]; Lesser Sunda Islands; Sunda Isles; Homo floresiensis; Adaptation, Biological; Animals; Biological Evolution; Body Height; Dwarfism; Gene Flow; Genome, Human; Humans; Indonesia; Islands; Neanderthals; Population; Selection, Genetic
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245786
作者单位	Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Lewis-Sigler Institute, Princeton University, Princeton, NJ, United States; Department of Life Sciences and Biotechnologies, University of Ferrara, Ferrara, Italy; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, United States; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Department of Computational Biology, Génopode, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Génopode, Quatier Sorge, Lausanne, Switzerland; Department of Linguistic and Cultural Evolution, Max Planck Institute for the Science of Human History, Jena, Germany; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland; Department of Genome Sciences, University of Washington, Seattle, WA, United States; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular ...
推荐引用方式 GB/T 7714	Tucci S.,Vohr S.H.,McCoy R.C.,et al. Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia[J],2018,361(6401).
APA	Tucci S..,Vohr S.H..,McCoy R.C..,Vernot B..,Robinson M.R..,...&Green R.E..(2018).Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia.Science,361(6401).
MLA	Tucci S.,et al."Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia".Science 361.6401(2018).