气候变化领域集成服务门户(CCPortal): The microbiome and human cancer

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DOI	10.1126/science.abc4552
	The microbiome and human cancer
	Sepich-Poore G.D.; Zitvogel L.; Straussman R.; Hasty J.; Wargo J.A.; Knight R.
发表日期	2021
ISSN	0036-8075
卷号	371 期号:6536
英文摘要	Microbial roles in cancer formation, diagnosis, prognosis, and treatment have been disputed for centuries. Recent studies have provocatively claimed that bacteria, viruses, and/or fungi are pervasive among cancers, key actors in cancer immunotherapy, and engineerable to treat metastases. Despite these findings, the number of microbes known to directly cause carcinogenesis remains small. Critically evaluating and building frameworks for such evidence in light of modern cancer biology is an important task. In this Review, we delineate between causal and complicit roles of microbes in cancer and trace common themes of their influence through the host's immune system, herein defined as the immuno-oncology-microbiome axis. We further review evidence for intratumoral microbes and approaches that manipulate the host's gut or tumor microbiome while projecting the next phase of experimental discovery. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	abiraterone acetate; BCG vaccine; doxorubicin; gemcitabine; talimogene laherparepvec; antiinfective agent; antineoplastic agent; cancer; chemotherapy; detection method; immune system; microorganism; adaptive immunity; Bacteroides fragilis; breast cancer; cancer therapy; clinical feature; colon cancer; colorectal cancer; diagnostic procedure; Fusobacterium nucleatum; host microbe interaction; human; immune system; intestine flora; lung adenocarcinoma; lung cancer; lymphoid organ; malignant neoplasm; melanoma; microbiome; non muscle invasive bladder cancer; nonhuman; oncology; pancreas cancer; priority journal; prostate cancer; Review; sarcoma; stomach cancer; stomach lymphoma; tumor microenvironment; bacterial phenomena and functions; bacterium; carcinogenesis; genetic engineering; genetics; immunology; immunomodulation; immunotherapy; lymphoid tissue; microbiology; microflora; neoplasm; oncolytic virotherapy; viral phenomena and functions; Adaptive Immunity; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Bacterial Physiological Phenomena; Carcinogenesis; Gastrointestinal Microbiome; Genetic Engineering; Host Microbial Interactions; Humans; Immunomodulation; Immunotherapy; Lymphoid Tissue; Microbiota; Neoplasms; Oncolytic Virotherapy; Tumor Microenvironment; Virus Physiological Phenomena
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245425
作者单位	Department of Bioengineering, University of California, San Diego, San Diego, CA, United States; Gustave Roussy Cancer Campus (GRCC), Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France; Institut National de la Santé et de la Recherche Medicale (INSERM) U1015, Villejuif, France; Université Paris-Sud, Université Paris-Saclay, Gustave Roussy, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; BioCircuits Institute, University of California, San Diego, San Diego, CA, United States; Molecular Biology Section, Division of Biological Science, University of California, San Diego, San Diego, CA, United States; Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, United States; Department of Genomic Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, United States; Department of Pediat...
推荐引用方式 GB/T 7714	Sepich-Poore G.D.,Zitvogel L.,Straussman R.,et al. The microbiome and human cancer[J],2021,371(6536).
APA	Sepich-Poore G.D.,Zitvogel L.,Straussman R.,Hasty J.,Wargo J.A.,&Knight R..(2021).The microbiome and human cancer.Science,371(6536).
MLA	Sepich-Poore G.D.,et al."The microbiome and human cancer".Science 371.6536(2021).