气候变化领域集成服务门户(CCPortal): Mammalian in vitro gametogenesis

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DOI	10.1126/science.aaz6830
	Mammalian in vitro gametogenesis
	Saitou M.; Hayashi K.
发表日期	2021
ISSN	0036-8075
卷号	374 期号:6563
英文摘要	Germ cells differentiate into sexually dimorphic gametes, oocytes, and spermatozoa, which unite to form new individuals. Accordingly, germ cell development entails intricate regulations of genome functions for genetic and epigenetic inheritance. The past decade has seen considerable advances in in vitro gametogenesis (IVG), which aims to recreate germ cell development from pluripotent stem cells (PSCs) in culture. Mouse PSCs can be induced into functional oocytes and spermatozoa, whereas human PSCs can be induced into early oocytes and prospermatogonia, promoting mechanistic understanding of mammalian germ cell development. The prospect for inducing human gametes with appropriate functions has been heightened, and such advances will create possibilities in reproductive medicine, including modeling infertility to explore remedies. The use of IVG-derived gametes for human reproduction will require careful legal and ethical discussions. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	biological development; cell; cell component; detection method; gamete; genome; germ cell; Mammalia; animal; cytology; ethics; female; human; in vitro study; Macaca fascicularis; male; mouse; oocyte; oocyte development; physiology; pluripotent stem cell; reproduction; sexual characteristics; spermatogenesis; spermatogonium; Animals; Female; Humans; In Vitro Techniques; Macaca fascicularis; Male; Mice; Oocytes; Oogenesis; Pluripotent Stem Cells; Reproduction; Reproductive Medicine; Sex Characteristics; Spermatogenesis; Spermatogonia
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245321
作者单位	Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan; Department of Developmental Stem Cell Biology, Faculty of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan; Department of Germline Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan
推荐引用方式 GB/T 7714	Saitou M.,Hayashi K.. Mammalian in vitro gametogenesis[J],2021,374(6563).
APA	Saitou M.,&Hayashi K..(2021).Mammalian in vitro gametogenesis.Science,374(6563).
MLA	Saitou M.,et al."Mammalian in vitro gametogenesis".Science 374.6563(2021).