气候变化领域集成服务门户(CCPortal): Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America

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DOI	10.1126/science.aal1988
	Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America
	Patin E.; Lopez M.; Grollemund R.; Verdu P.; Harmant C.; Quach H.; Laval G.; Perry G.H.; Barreiro L.B.; Froment A.; Heyer E.; Massougbodji A.; Fortes-Lima C.; Migot-Nabias F.; Bellis G.; Dugoujon J.-M.; Pereira J.B.; Fernandes V.; Pereira L.; Van Der Veen L.; Mouguiama-Daouda P.; Bustamante C.D.; Hombert J.-M.; Quintana-Murci L.
发表日期	2017
ISSN	0036-8075
起始页码	543
结束页码	546
卷号	356 期号:6337
英文摘要	Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 populations in western central Africa, where Bantu languages originated. We found that early Bantu speakers first moved southward, through the equatorial rainforest, before spreading toward eastern and southern Africa. We also found that genetic adaptation of Bantu speakers was facilitated by admixture with local populations, particularly for the HLA and LCT loci. Finally, we identified a major contribution of western central African Bantu speakers to the ancestry of African Americans, whose genomes present no strong signals of natural selection. Together, these results highlight the contribution of Bantu-speaking peoples to the complex genetic history of Africans and African Americans. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	adaptation; genetic analysis; genomics; human evolution; natural selection; Africa; African; African American; Article; Central Africa; Central African; evolutionary adaptation; gene locus; genome; genomics; human; language; major clinical study; natural selection; North America; population; population dispersal; priority journal; rain forest; speech; adaptation; gene locus; genetics; language; migration; single nucleotide polymorphism; speech; Central Africa; North America; HLA antigen; lactase; Adaptation, Physiological; Africa, Central; African Americans; Genetic Loci; HLA Antigens; Human Migration; Humans; Lactase; Language; North America; Polymorphism, Single Nucleotide; Rainforest; Speech
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245009
作者单位	Human Evolutionary Genetics, Institut Pasteur, Paris, 75015, France; Centre National de La Recherche Scientifique URA3012, Paris, 75015, France; Center of Bioinformatics, Biostatistics, and Integrative Biology, Institut Pasteur, Paris, 75015, France; Evolutionary Biology Group, School of Biological Sciences, University of Reading, Reading, RG6 6BX, United Kingdom; Departments of English and Anthropology, University of Missouri, Columbia, MO 65211, United States; Centre National de La Recherche Scientifique UMR7206, Muséum National d'Histoire Naturelle, Université Paris Diderot, Sorbonne Paris Cité, Paris, 75016, France; Departments of Anthropology and Biology, Pennsylvania State University, University Park, PA 16802, United States; Université de Montréal, Centre de Recherche CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada; Institut de Recherche Pour Le Développement, UMR 208, Muséum National d'Histoire Naturelle, Paris, 75005, France; Centre d'Etude et de Recherche Sur Le Paludisme Associé à la Grosse...
推荐引用方式 GB/T 7714	Patin E.,Lopez M.,Grollemund R.,et al. Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America[J],2017,356(6337).
APA	Patin E..,Lopez M..,Grollemund R..,Verdu P..,Harmant C..,...&Quintana-Murci L..(2017).Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.Science,356(6337).
MLA	Patin E.,et al."Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America".Science 356.6337(2017).