气候变化领域集成服务门户(CCPortal): A global brain state underlies C. Elegans sleep behavior

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DOI	10.1126/science.aam6851
	A global brain state underlies C. Elegans sleep behavior
	Nichols A.L.A.; Eichler T.; Latham R.; Zimmer M.
发表日期	2017
ISSN	0036-8075
起始页码	1247
结束页码	1256
卷号	356 期号:6344
英文摘要	How the brain effectively switches between and maintains global states, such as sleep and wakefulness, is not yet understood.We used brainwide functional imaging at single-cell resolution to show that during the developmental stage of lethargus, the Caenorhabditis elegans brain is predisposed to global quiescence, characterized by systemic down-regulation of neuronal activity. Only a few specific neurons are exempt from this effect. In the absence of external arousing cues, this quiescent brain state arises by the convergence of neuronal activities toward a fixed-point attractor embedded in an otherwise dynamic neural state space. We observed efficient spontaneous and sensory-evoked exits from quiescence. Our data support the hypothesis that during global states such as sleep, neuronal networks are drawn to a baseline mode and can be effectively reactivated by signaling from arousing circuits. © The Authors, some rights reserved.
英文关键词	brain; cells and cell components; developmental stage; nematode; sleep; arousal; Article; behavior genetics; brain function; Caenorhabditis elegans; developmental stage; down regulation; genetic background; interneuron; larval stage; lethargy; neuroimaging; nonhuman; population dynamics; priority journal; sensory nerve cell; sleep; wakefulness; animal; animal behavior; brain; Caenorhabditis elegans; environment; genetics; metabolism; mutation; nerve cell network; physiology; signal transduction; sleep; Caenorhabditis elegans; neuropeptide receptor; oxygen; Animals; Arousal; Behavior, Animal; Brain; Caenorhabditis elegans; Environment; Mutation; Nerve Net; Oxygen; Receptors, Neuropeptide; Sensory Receptor Cells; Signal Transduction; Sleep
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244879
作者单位	Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, Vienna, 1030, Austria
推荐引用方式 GB/T 7714	Nichols A.L.A.,Eichler T.,Latham R.,et al. A global brain state underlies C. Elegans sleep behavior[J],2017,356(6344).
APA	Nichols A.L.A.,Eichler T.,Latham R.,&Zimmer M..(2017).A global brain state underlies C. Elegans sleep behavior.Science,356(6344).
MLA	Nichols A.L.A.,et al."A global brain state underlies C. Elegans sleep behavior".Science 356.6344(2017).