气候变化领域集成服务门户(CCPortal): Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats

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DOI	10.1126/science.aaj1497
	Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats
	Moore J.J.; Ravassard P.M.; Ho D.; Acharya L.; Kees A.L.; Vuong C.; Mehta M.R.
发表日期	2017
ISSN	0036-8075
卷号	355 期号:6331
英文摘要	Neural activity in vivo is primarily measured using extracellular somatic spikes, which provide limited information about neural computation. Hence, it is necessary to record from neuronal dendrites, which can generate dendritic action potentials (DAPs) in vitro, which can profoundly influence neural computation and plasticity.We measured neocortical sub- and suprathreshold dendritic membrane potential (DMP) from putative distal-most dendrites using tetrodes in freely behaving rats over multiple days with a high degree of stability and submillisecond temporal resolution. DAP firing rates were several-fold larger than somatic rates. DAP rates were also modulated by subthreshold DMP fluctuations, which were far larger than DAP amplitude, indicating hybrid, analog-digital coding in the dendrites. Parietal DAP and DMP exhibited egocentric spatial maps comparable to pyramidal neurons. These results have important implications for neural coding and plasticity.
英文关键词	anatomy; cells and cell components; membrane; neurology; physiology; rodent; animal behavior; cell membrane potential; Conference Paper; dendritic cell; electrode; encapsulation; glia cell; immune response; immunohistochemistry; molecular dynamics; nerve cell plasticity; nonhuman; priority journal; pyramidal nerve cell; spike; action potential; animal; animal behavior; brain cortex; cytology; dendrite; electrode implant; glia; Long Evans cinnamon rat; male; membrane potential; physiology; rat; sleep; Rattus; Action Potentials; Animals; Behavior, Animal; Cerebral Cortex; Dendrites; Electrodes, Implanted; Male; Membrane Potentials; Neuroglia; Pyramidal Cells; Rats; Rats, Inbred LEC; Sleep
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244812
作者单位	W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, United States; Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA 90095, United States; Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, United States; Departments of Neurology and Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, United States
推荐引用方式 GB/T 7714	Moore J.J.,Ravassard P.M.,Ho D.,et al. Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats[J],2017,355(6331).
APA	Moore J.J..,Ravassard P.M..,Ho D..,Acharya L..,Kees A.L..,...&Mehta M.R..(2017).Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats.Science,355(6331).
MLA	Moore J.J.,et al."Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats".Science 355.6331(2017).