气候变化领域集成服务门户(CCPortal): Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

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DOI	10.1126/science.aat8078
	Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
	Moda-Sava R.N.; Murdock M.H.; Parekh P.K.; Fetcho R.N.; Huang B.S.; Huynh T.N.; Witztum J.; Shaver D.C.; Rosenthal D.L.; Alway E.J.; Lopez K.; Meng Y.; Nellissen L.; Grosenick L.; Milner T.A.; Deisseroth K.; Bito H.; Kasai H.; Liston C.
发表日期	2019
ISSN	0036-8075
卷号	364 期号:6436
英文摘要	The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging of medial prefrontal microcircuits in the living brain, we found that prefrontal spinogenesis plays a critical role in sustaining specific antidepressant behavioral effects and maintaining long-term behavioral remission. Depression-related behavior was associated with targeted, branch-specific elimination of postsynaptic dendritic spines on prefrontal projection neurons. Antidepressant-dose ketamine reversed these effects by selectively rescuing eliminated spines and restoring coordinated activity in multicellular ensembles that predict motivated escape behavior. Prefrontal spinogenesis was required for the long-term maintenance of antidepressant effects on motivated escape behavior but not for their initial induction. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	antidepressant agent; ketamine; antidepressant agent; corticosterone; biology; brain; escape behavior; neurology; adult; animal cell; animal experiment; animal model; antidepressant activity; Article; biological model; brain dysfunction; cell function; chronic stress; controlled study; dendritic spine; depression; mouse; nerve cell differentiation; nerve projection; nerve stimulation; nervous system development; nonhuman; prediction; prefrontal cortex; priority journal; remission; young adult; animal; C57BL mouse; chemically induced; dendritic spine; disease model; drug effect; escape behavior; mental stress; nerve cell plasticity; pathology; pathophysiology; physiology; prefrontal cortex; synapse; transgenic mouse; Animals; Antidepressive Agents; Corticosterone; Dendritic Spines; Depressive Disorder; Disease Models, Animal; Escape Reaction; Ketamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Prefrontal Cortex; Stress, Psychological; Synapses
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244796
作者单位	Brain and Mind Research Institute, Department of Psychiatry, Sackler Institute for Developmental Psychobiology, Weill Cornell Medicine, New York, NY 10021, United States; Departments of Bioengineering and of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States; Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan
推荐引用方式 GB/T 7714	Moda-Sava R.N.,Murdock M.H.,Parekh P.K.,et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation[J],2019,364(6436).
APA	Moda-Sava R.N..,Murdock M.H..,Parekh P.K..,Fetcho R.N..,Huang B.S..,...&Liston C..(2019).Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.Science,364(6436).
MLA	Moda-Sava R.N.,et al."Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation".Science 364.6436(2019).