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DOI	10.1126/SCIENCE.ABC8511
	Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
	Mathew D.; Giles J.R.; Baxter A.E.; Oldridge D.A.; Greenplate A.R.; Wu J.E.; Alanio C.; Kuri-Cervantes H.; Pampena M.B.; D'Andrea K.; Manne S.; Chen Z.; Huang Y.J.; Reilly J.P.; Weisman A.R.; Ittner C.A.G.; Kuthuru O.; Dougherty J.; Nzingha K.; Han N.; Kim J.; Pattekar A.; Goodwin E.C.; Anderson E.M.; Weirick M.E.; Gouma S.; Arevalo C.P.; Bolton M.J.; Chen F.; Lacey S.F.; Ramage H.; Cherry S.; Hensley S.E.; Apostolidis S.A.; Huang A.C.; Vella L.A.; Betts M.R.; Meyer N.J.; Wherry E.J.; Alam Z.; Addison M.M.; Byrne K.T.; Chandra A.; Descamps H.C.; Kaminskiy Y.; Hamilton J.T.; Noll J.H.; Omran D.K.; Perkey E.; Prager E.M.; Pueschl D.; Shah J.B.; Shilan J.S.; Vanderbeck A.N.; UPenn COVID Processing Unit
发表日期	2020
ISSN	0036-8075
卷号	369 期号:6508
英文摘要	Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable with that in uninfected individuals. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19. Copyright © 2020 The Authors, some rights reserved.
英文关键词	ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1; HLA DR antigen; Ki 67 antigen; SARS-CoV-2 antibody; cytokine; virus antibody; cell; disease severity; disease treatment; immune response; viral disease; virus; adaptive immunity; adult; Article; CD4+ T lymphocyte; CD8+ T lymphocyte; clinical feature; cohort analysis; comparative study; controlled study; coronavirus disease 2019; cytometry; disease course; disease severity; hospitalization; human; human cell; immunology; lymphocyte proliferation; major clinical study; memory cell; middle aged; mortality; observational study; plasmablast; priority journal; protein expression; Severe acute respiratory syndrome coronavirus 2; T lymphocyte activation; Tfh cell; virus immunity; aged; B lymphocyte; B lymphocyte subpopulation; Betacoronavirus; blood; Coronavirus infection; female; helper cell; immunological memory; lymphocyte activation; male; pandemic; plasma cell; severity of illness index; T lymphocyte; T lymphocyte subpopulation; time factor; very elderly; virus pneumonia; young adult; Coronavirus; Adaptive Immunity; Adult; Aged; Aged, 80 and over; Antibodies, Viral; B-Lymphocyte Subsets; B-Lymphocytes; Betacoronavirus; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Coronavirus Infections; Cytokines; Female; Humans; Immunologic Memory; Lymphocyte Activation; Male; Middle Aged; Pandemics; Plasma Cells; Pneumonia, Viral; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Time Factors; Young Adult
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244679
作者单位	Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA...
推荐引用方式 GB/T 7714	Mathew D.,Giles J.R.,Baxter A.E.,et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications[J],2020,369(6508).
APA	Mathew D..,Giles J.R..,Baxter A.E..,Oldridge D.A..,Greenplate A.R..,...&UPenn COVID Processing Unit.(2020).Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications.Science,369(6508).
MLA	Mathew D.,et al."Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications".Science 369.6508(2020).