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| DOI | 10.1126/science.aat6806 |
| Dynamic DNA methylation: In the right place at the right time | |
| Luo C.; Hajkova P.; Ecker J.R. | |
| 发表日期 | 2018 |
| ISSN | 0036-8075 |
| 起始页码 | 1336 |
| 结束页码 | 1340 |
| 卷号 | 361期号:6409 |
| 英文摘要 | The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC) regulation depicts this covalent modification as a stable repressive regulator of promoter activity. However, whole-genome analysis of 5mC reveals widespread tissue- and cell type–specific patterns and pervasive dynamics during mammalian development. Here we review recent findings that delineate 5mC functions in developmental stages and diverse genomic compartments as well as discuss the molecular mechanisms that connect transcriptional regulation and 5mC. Beyond the newly appreciated dynamics, regulatory roles for 5mC have been suggested in new biological contexts, such as learning and memory or aging. The use of new single-cell measurement techniques and precise editing tools will enable functional analyses of 5mC in gene expression, clarifying its role in various biological processes. © 2017 The Authors. |
| 英文关键词 | 5 methylcytosine; CRISPR associated endonuclease Cas9; cytosine; dioxygenase; DNA methyltransferase 3A; DNA methyltransferase 3B; histone H3; methyl CpG binding protein 2; RE1 silencing transcription factor; ten eleven translocation methylcytosine dioxygenase; transcription activator like effector; transcription factor; transcription factor CTCF; unclassified drug; zinc finger protein; 5 methylcytosine; transcription factor; biology; detection method; developmental biology; DNA; gene expression; genome; mammal; methylation; aging; developmental stage; DNA methylation; gene editing; gene expression; genetic transcription; genomics; human; hydroxymethylation; learning; memory; methylation; nonhuman; priority journal; Review; sequence analysis; single cell bisulfite sequencing; single cell reduced representation bisulfite sequencing; transcription regulation; animal; diseases; gene expression regulation; genetics; memory; metabolism; neoplasm; single cell analysis; Mammalia; 5-Methylcytosine; Aging; Animals; Disease; DNA Methylation; Gene Editing; Gene Expression Regulation, Developmental; Humans; Memory; Neoplasms; Single-Cell Analysis; Transcription Factors; Transcription, Genetic |
| 语种 | 英语 |
| 来源期刊 | Science
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/244597 |
| 作者单位 | Genomic Analysis Laboratory, Salk Institute for Biological Studies, San Diego, CA 92037, United States; Howard Hughes Medical Institute, Salk Institute for Biological Studies, San Diego, CA 92037, United States; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, United Kingdom; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, United Kingdom |
| 推荐引用方式 GB/T 7714 | Luo C.,Hajkova P.,Ecker J.R.. Dynamic DNA methylation: In the right place at the right time[J],2018,361(6409). |
| APA | Luo C.,Hajkova P.,&Ecker J.R..(2018).Dynamic DNA methylation: In the right place at the right time.Science,361(6409). |
| MLA | Luo C.,et al."Dynamic DNA methylation: In the right place at the right time".Science 361.6409(2018). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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