气候变化领域集成服务门户(CCPortal): The pan-genome effector-triggered immunity landscape of a host-pathogen interaction

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DOI	10.1126/science.aax4079
	The pan-genome effector-triggered immunity landscape of a host-pathogen interaction
	Laflamme B.; Dillon M.M.; Martel A.; Almeida R.N.D.; Desveaux D.; Guttman D.S.
发表日期	2020
ISSN	0036-8075
起始页码	763
结束页码	768
卷号	367 期号:6479
英文摘要	Effector-triggered immunity (ETI), induced by host immune receptors in response to microbial effectors, protects plants against virulent pathogens. However, a systematic study of ETI prevalence against species-wide pathogen diversity is lacking. We constructed the Pseudomonas syringae Type III Effector Compendium (PsyTEC) to reduce the pan-genome complexity of 5127 unique effector proteins, distributed among 70 families from 494 strains, to 529 representative alleles. We screened PsyTEC on the model plant Arabidopsis thaliana and identified 59 ETI-eliciting alleles (11.2%) from 19 families (27.1%), with orthologs distributed among 96.8% of P. syringae strains. We also identified two previously undescribed host immune receptors, including CAR1, which recognizes the conserved effectors AvrE and HopAA1, and found that 94.7% of strains harbor alleles predicted to be recognized by either CAR1 or ZAR1. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	genome; herb; host-pathogen interaction; immunity; microbial ecology; protein; virulence; allele; Arabidopsis thaliana; article; host pathogen interaction; immunity; major clinical study; nonhuman; orthology; Pseudomonas syringae; Arabidopsis; genetics; host pathogen interaction; immunology; innate immunity; microbiology; pathogenicity; physiology; plant disease; plant genome; plant immunity; Arabidopsis thaliana; Pseudomonas syringae; Arabidopsis protein; AvrE protein, Pseudomonas syringae; bacterial protein; carrier protein; ZAR1 protein, Arabidopsis; Arabidopsis; Arabidopsis Proteins; Bacterial Proteins; Carrier Proteins; Genome, Plant; Host-Pathogen Interactions; Immunity, Innate; Plant Diseases; Plant Immunity; Pseudomonas syringae
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244434
作者单位	Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada; Center for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3B2, Canada
推荐引用方式 GB/T 7714	Laflamme B.,Dillon M.M.,Martel A.,et al. The pan-genome effector-triggered immunity landscape of a host-pathogen interaction[J],2020,367(6479).
APA	Laflamme B.,Dillon M.M.,Martel A.,Almeida R.N.D.,Desveaux D.,&Guttman D.S..(2020).The pan-genome effector-triggered immunity landscape of a host-pathogen interaction.Science,367(6479).
MLA	Laflamme B.,et al."The pan-genome effector-triggered immunity landscape of a host-pathogen interaction".Science 367.6479(2020).