气候变化领域集成服务门户(CCPortal): Antibody-dependent enhancement of severe dengue disease in humans

CCPortal

DOI	10.1126/science.aan6836
	Antibody-dependent enhancement of severe dengue disease in humans
	Katzelnick L.C.; Gresh L.; Halloran M.E.; Mercado J.C.; Kuan G.; Gordon A.; Balmaseda A.; Harris E.
发表日期	2017
ISSN	0036-8075
起始页码	929
结束页码	932
卷号	358 期号:6365
英文摘要	For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers. By contrast, we observe protection from all symptomatic dengue disease at high antibody titers. Thus, immune correlates of severe dengue must be evaluated separately from correlates of protection against symptomatic disease. These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	dengue vaccine; dengue vaccine; virus antibody; antibody; dengue fever; health risk; immune response; laboratory method; pathogenicity; statistical analysis; symptom; vaccine; virus; adolescent; antibody dependent enhancement; antibody titer; antigen binding; Article; child; controlled study; correlation analysis; dengue; disease severity; human; immune system; infection risk; major clinical study; Nicaragua; pathogenesis; priority journal; blood; cohort analysis; dengue; female; immunology; male; preschool child; virology; Nicaragua; Animalia; Dengue virus group; Adolescent; Antibodies, Viral; Antibody-Dependent Enhancement; Child; Child, Preschool; Cohort Studies; Dengue; Dengue Vaccines; Female; Humans; Male
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244233
作者单位	Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, United States; Sustainable Sciences Institute, Managua, Nicaragua; Department of Biostatistics, University of WashingtonWA, United States; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua; Centro de Salud Sócrates Flores Vivas, Ministry of Health, Managua, Nicaragua; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States
推荐引用方式 GB/T 7714	Katzelnick L.C.,Gresh L.,Halloran M.E.,et al. Antibody-dependent enhancement of severe dengue disease in humans[J],2017,358(6365).
APA	Katzelnick L.C..,Gresh L..,Halloran M.E..,Mercado J.C..,Kuan G..,...&Harris E..(2017).Antibody-dependent enhancement of severe dengue disease in humans.Science,358(6365).
MLA	Katzelnick L.C.,et al."Antibody-dependent enhancement of severe dengue disease in humans".Science 358.6365(2017).