气候变化领域集成服务门户(CCPortal): Endemic persistence of a highly contagious pathogen: Foot-and-mouth disease in its wildlife host

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DOI	10.1126/science.abd2475
	Endemic persistence of a highly contagious pathogen: Foot-and-mouth disease in its wildlife host
	Jolles A.; Gorsich E.; Gubbins S.; Beechler B.; Buss P.; Juleff N.; de Klerk-Lorist L.-M.; Maree F.; Perez-Martin E.; van Schalkwyk O.L.; Scott K.; Zhang F.; Medlock J.; Charleston B.
发表日期	2021
ISSN	0036-8075
起始页码	104
结束页码	109
卷号	374 期号:6563
英文摘要	Extremely contagious pathogens are a global biosecurity threat because of their high burden of morbidity and mortality, as well as their capacity for fast-moving epidemics that are difficult to quell. Understanding the mechanisms enabling persistence of highly transmissible pathogens in host populations is thus a central problem in disease ecology. Through a combination of experimental and theoretical approaches, we investigated how highly contagious foot-and-mouth disease viruses persist in the African buffalo, which serves as their wildlife reservoir. We found that viral persistence through transmission among acutely infected hosts alone is unlikely. However, the inclusion of occasional transmission from persistently infected carriers reliably rescues the most infectious viral strain from fade-out. Additional mechanisms such as antigenic shift, loss of immunity, or spillover among host populations may be required for persistence of less transmissible strains. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	cattle; detection method; disease transmission; immunity; persistence; viral disease; Syncerus caffer; animal; buffalo; endemic disease; foot and mouth disease; Foot and mouth disease virus; isolation and purification; pathogenicity; population; veterinary medicine; virology; zoonosis; Animals; Buffaloes; Endemic Diseases; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Population; Zoonoses
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244190
作者单位	Department of Biomedical Sciences, Oregon State University, Corvallis, OR 97331, United States; Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, United States; Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research, University of Warwick, Coventry, CV4 7AL, United Kingdom; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom; The Pirbright Institute, Ash Road, Surrey, Pirbright, GU24 0NF, United Kingdom; SANParks, Veterinary Wildlife Services, Kruger National Park, Skukuza, 1350, South Africa; Bill and Melinda Gates Foundation, Livestock Program, Seattle, WA 98109, United States; Office of the State Veterinarian, Department of Agriculture, Land Reform and Rural Development, Government of South Africa, Skukuza, 1350, South Africa; Vaccine and Diagnostic Research Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Private Bag X05, Onderstepoort, 0110, South Africa; South Africa Department of ...
推荐引用方式 GB/T 7714	Jolles A.,Gorsich E.,Gubbins S.,et al. Endemic persistence of a highly contagious pathogen: Foot-and-mouth disease in its wildlife host[J],2021,374(6563).
APA	Jolles A..,Gorsich E..,Gubbins S..,Beechler B..,Buss P..,...&Charleston B..(2021).Endemic persistence of a highly contagious pathogen: Foot-and-mouth disease in its wildlife host.Science,374(6563).
MLA	Jolles A.,et al."Endemic persistence of a highly contagious pathogen: Foot-and-mouth disease in its wildlife host".Science 374.6563(2021).