气候变化领域集成服务门户(CCPortal): Mosquito heat seeking is driven by an ancestral cooling receptor

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DOI	10.1126/science.aay9847
	Mosquito heat seeking is driven by an ancestral cooling receptor
	Greppi C.; Laursen W.J.; Budelli G.; Chang E.C.; Daniels A.M.; van Giesen L.; Smidler A.L.; Catteruccia F.; Garrity P.A.
发表日期	2020
ISSN	0036-8075
起始页码	681
结束页码	684
卷号	367 期号:6478
英文摘要	Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown. Here, we identify ionotropic receptor IR21a, a receptor conserved throughout insects, as a key mediator of heat seeking in the malaria vector Anopheles gambiae. Although Ir21a mediates heat avoidance in Drosophila, we find it drives heat seeking and heat-stimulated blood feeding in Anopheles. At a cellular level, Ir21a is essential for the detection of cooling, suggesting that during evolution mosquito heat seeking relied on cooling-mediated repulsion. Our data indicate that the evolution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non–blood-feeding Diptera. Copyright © 2020 The Authors.
英文关键词	ionotropic receptor; ionotropic receptor 21a; transient receptor potential channel A1; unclassified drug; ancestry; cooling; disease transmission; disease vector; fly; hemophagy; malaria; mosquito; protein; adult; Aedes aegypti; allele; animal experiment; animal tissue; Anopheles gambiae; Article; controlled study; cooling; Drosophila melanogaster; female; genome-wide association study; heat acclimatization; heat sensitivity; human; immunohistochemistry; male; mosquito; mosquito vector; nonhuman; priority journal; protein expression; protein localization; sanguivore; signal noise ratio; warming; Anopheles gambiae; Diptera; Hexapoda
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243869
作者单位	Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, United States; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, United States; Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115, United States
推荐引用方式 GB/T 7714	Greppi C.,Laursen W.J.,Budelli G.,et al. Mosquito heat seeking is driven by an ancestral cooling receptor[J],2020,367(6478).
APA	Greppi C..,Laursen W.J..,Budelli G..,Chang E.C..,Daniels A.M..,...&Garrity P.A..(2020).Mosquito heat seeking is driven by an ancestral cooling receptor.Science,367(6478).
MLA	Greppi C.,et al."Mosquito heat seeking is driven by an ancestral cooling receptor".Science 367.6478(2020).