气候变化领域集成服务门户(CCPortal): Population genetics of the coroal Acropora millepora: Toward genomic prediction of bleaching

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DOI	10.1126/science.aba4674
	Population genetics of the coroal Acropora millepora: Toward genomic prediction of bleaching
	Fuller Z.L.; Mocellin V.J.L.; Morris L.A.; Cantin N.; Shepherd J.; Sarre L.; Peng J.; Liao Y.; Pickrell J.; Andolfatto P.; Matz M.; Bay L.K.; Przeworski M.
发表日期	2020
ISSN	0036-8075
卷号	369 期号:6501
英文摘要	Although reef-building corals are declining worldwide, responses to bleaching vary within and across species and are partly heritable. Toward predicting bleaching response from genomic data, we generated a chromosome-scale genome assembly for the coral Acropora millepora. We obtained whole-genome sequences for 237 phenotyped samples collected at 12 reefs along the Great Barrier Reef, among which we inferred little population structure. Scanning the genome for evidence of local adaptation, we detected signatures of long-term balancing selection in the heat-shock co-chaperone sacsin. We conducted a genome-wide association study of visual bleaching score for 213 samples, incorporating the polygenic score derived from it into a predictive model for bleaching in the wild. These results set the stage for genomics-based approaches in conservation strategies. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	chaperone; heat shock protein; sacsin protein; unclassified drug; bleaching; chromosome; coral; genome; heat shock; local adaptation; phenotype; population genetics; population structure; Acropora millepora; Article; bleaching; coral reef; evolutionary adaptation; gene structure; genetic conservation; genetic risk score; genetic selection; genetic variation; genome-wide association study; genomics; heat tolerance; heritability; nonhuman; phenotype; population genetics; population structure; prediction; priority journal; whole genome sequencing; wild species; adaptation; animal; Anthozoa; genetics; genome; genomics; population genetics; Australia; Coral Sea; Great Barrier Reef; Queensland; Acropora millepora; Anthozoa; Adaptation, Physiological; Animals; Anthozoa; Coral Reefs; Genetics, Population; Genome; Genome-Wide Association Study; Genomics
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243753
作者单位	Department of Biological Sciences, Columbia University, New York, NY, United States; Australian Institute of Marine Science, Townsville, QLD, Australia; AIMS@JCU, Australian Institute of Marine Science, College of Science and Engineering, James Cook University, Townsville, QLD, Australia; College of Science and Engineering, James Cook University, Townsville, QLD, Australia; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States; Department of Integrative Biology, University of Texas at Austin, Austin, TX, United States; Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, United States; Gencove, New York, NY, United States; Department of Systems Biology, Columbia University, New York, NY, United States; Program for Mathematical Genomics, Columbia University, New York, NY, United States
推荐引用方式 GB/T 7714	Fuller Z.L.,Mocellin V.J.L.,Morris L.A.,et al. Population genetics of the coroal Acropora millepora: Toward genomic prediction of bleaching[J],2020,369(6501).
APA	Fuller Z.L..,Mocellin V.J.L..,Morris L.A..,Cantin N..,Shepherd J..,...&Przeworski M..(2020).Population genetics of the coroal Acropora millepora: Toward genomic prediction of bleaching.Science,369(6501).
MLA	Fuller Z.L.,et al."Population genetics of the coroal Acropora millepora: Toward genomic prediction of bleaching".Science 369.6501(2020).