气候变化领域集成服务门户(CCPortal): Co-regulatory networks of human serum proteins link genetics to disease

CCPortal

DOI	10.1126/science.aaq1327
	Co-regulatory networks of human serum proteins link genetics to disease
	Emilsson V.; Ilkov M.; Lamb J.R.; Finkel N.; Gudmundsson E.F.; Pitts R.; Hoover H.; Gudmundsdottir V.; Horman S.R.; Aspelund T.; Shu L.; Trifonov V.; Sigurdsson S.; Manolescu A.; Zhu J.; Olafsson Ö.; Jakobsdottir J.; Lesley S.A.; To J.; Zhang J.; Harris T.B.; Launer L.J.; Zhang B.; Eiriksdottir G.; Yang X.; Orth A.P.; Jennings L.L.; Gudnason V.
发表日期	2018
ISSN	0036-8075
卷号	361 期号:6404
英文摘要	Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states. 2017 © The Authors
英文关键词	ELAV like protein 2; aptamer; plasma protein; proteome; correlation; disease; genetics; protein; serum; age; Article; cardiovascular disease assessment; disease association; gene expression regulation; gene locus; gene regulatory network; genetic association; genetic association study; genetic variability; human; immune response; immunoregulation; metabolic disorder; overall survival; prediction; priority journal; protein blood level; protein structure; single nucleotide polymorphism; cardiovascular disease; genetic predisposition; genetic variation; genetics; Iceland; metabolism; procedures; proteomics; Iceland; Aptamers, Nucleotide; Blood Proteins; Cardiovascular Diseases; Genetic Predisposition to Disease; Genetic Variation; Humans; Iceland; Metabolic Diseases; Metabolic Networks and Pathways; Proteome; Proteomics
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243616
作者单位	Icelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland; Faculty of Pharmacology, University of Iceland, Reykjavik, 101, Iceland; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, United States; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA 02139, United States; Centre of Public Health Sciences, University of Iceland, Reykjavik, 101, Iceland; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, United States; School of Science and Engineering, Reykjavik University, Mentavegur 1, IS-101, Reykjavik, 101, Iceland; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892-9205, United States; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
推荐引用方式 GB/T 7714	Emilsson V.,Ilkov M.,Lamb J.R.,et al. Co-regulatory networks of human serum proteins link genetics to disease[J],2018,361(6404).
APA	Emilsson V..,Ilkov M..,Lamb J.R..,Finkel N..,Gudmundsson E.F..,...&Gudnason V..(2018).Co-regulatory networks of human serum proteins link genetics to disease.Science,361(6404).
MLA	Emilsson V.,et al."Co-regulatory networks of human serum proteins link genetics to disease".Science 361.6404(2018).