气候变化领域集成服务门户(CCPortal): Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy

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DOI	10.1126/science.4001946
	Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy
	Deuel R.K.; Yue G.M.; Sherman W.R.; Schickner D.J.; Ackerman J.J.H.
发表日期	1985
ISSN	0036-8075
起始页码	1329
结束页码	1331
卷号	228 期号:4705
英文摘要	The phosphorylation of 2-deoxyglucose by the mammalian brain is used as an index of the brain's energy metabolism. The results of phosphorus-31 nuclear magnetic resonance (31P NMR) monitoring of conscious animals in vivo showed rapid phosphorylation of 2-deoxyglucose by brain tissue. The rate of phosphorylation as determined by 31P NMR was consistent with results achieved by tracer methods using carbon-14-labeled 2-deoxyglucose. However, the disappearance of 2-deoxyglucose-6-phosphate was shown to be faster than that reported by tracer studies and occurred without alterations of intracellular pH and energy homeostasis. These results were confirmed by gas chromatography and mass spectroscopy. It is postulated that 2-deoxyglucose may be metabolized in several ways, including dephosphorylation by a hexose phosphatase.
英文关键词	deoxyglucose; animal experiment; brain metabolism; central nervous system; energy transfer; nonhuman; nuclear magnetic resonance; priority journal; rat; Animals; Brain; Deoxy Sugars; Deoxyglucose; Kinetics; Magnetic Resonance Spectroscopy; Phosphorylation; Rats; Rats, Inbred Strains; Animalia; Mammalia
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243523
作者单位	Departments of Pediatrics and Neurology, McDonnell Center for Study of Higher Brain Function, Washington University School of Medicine, St. Louis, MO 63178; Department of Internal Medicine, Washington University School of Medicine; Departments of Psychiatry and Biological Chemistry, Washington University School of Medicine; Department of Chemistry, Washington University
推荐引用方式 GB/T 7714	Deuel R.K.,Yue G.M.,Sherman W.R.,et al. Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy[J],1985,228(4705).
APA	Deuel R.K.,Yue G.M.,Sherman W.R.,Schickner D.J.,&Ackerman J.J.H..(1985).Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy.Science,228(4705).
MLA	Deuel R.K.,et al."Monitoring the time course of cerebral deoxyglucose metabolism by 31P nuclear magnetic resonance spectroscopy".Science 228.4705(1985).