气候变化领域集成服务门户(CCPortal): Ultrastructural evidence for synaptic scaling across the wake/sleep cycle

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DOI	10.1126/science.aah5982
	Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
	De Vivo L.; Bellesi M.; Marshall W.; Bushong E.A.; Ellisman M.H.; Tononi G.; Cirelli C.
发表日期	2017
ISSN	0036-8075
起始页码	507
结束页码	510
卷号	355 期号:6324
英文摘要	It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic and informational considerations suggest that potentiation should occur primarily during wake, when animals learn, and depression should occur during sleep. We measured 6920 synapses in mouse motor and sensory cortices using three-dimensional electron microscopy. The axon-spine interface (ASI) decreased ∼18% after sleep compared with wake. This decrease was proportional to ASI size, which is indicative of scaling. Scaling was selective, sparing synapses that were large and lacked recycling endosomes. Similar scaling occurred for spine head volume, suggesting a distinction between weaker, more plastic synapses (∼80%) and stronger, more stable synapses. These results support the hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	membrane protein; molecular marker; animal; behavioral response; learning; nervous system; neurology; rodent; sleep; ultrastructure; Article; auditory cortex; axon; brain region; cell membrane; controlled study; dendrite; electron microscopy; endoplasmic reticulum; endosome; environmental change; head; mitochondrion; Monte Carlo method; motor cortex; mouse; multivesicular body; nerve cell; nerve cell plasticity; nonhuman; priority journal; sensory cortex; sleep waking cycle; spine; synapse; synapse vesicle; animal; learning; long term potentiation; physiology; sleep; somatosensory cortex; synapse; ultrastructure; wakefulness; Animalia; Animals; Axons; Learning; Long-Term Potentiation; Mice; Microscopy, Electron; Motor Cortex; Sleep; Somatosensory Cortex; Spine; Synapses; Wakefulness
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243489
作者单位	Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, United States; Department of Experimental and Clinical Medicine, Section of Neuroscience and Cell Biology, Università Politecnica delle Marche, Ancona, Italy; National Center for Microscopy and Imaging Research, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, United States; Department of Neurosciences, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, United States
推荐引用方式 GB/T 7714	De Vivo L.,Bellesi M.,Marshall W.,et al. Ultrastructural evidence for synaptic scaling across the wake/sleep cycle[J],2017,355(6324).
APA	De Vivo L..,Bellesi M..,Marshall W..,Bushong E.A..,Ellisman M.H..,...&Cirelli C..(2017).Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.Science,355(6324).
MLA	De Vivo L.,et al."Ultrastructural evidence for synaptic scaling across the wake/sleep cycle".Science 355.6324(2017).