气候变化领域集成服务门户(CCPortal): Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

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DOI	10.1126/science.aav5427
	Major subpopulations of Plasmodium falciparum in sub-Saharan Africa
	Amambua-Ngwa A.; Amenga-Etego L.; Kamau E.; Amato R.; Ghansah A.; Golassa L.; Randrianarivelojosia M.; Ishengoma D.; Apinjoh T.; Maïga-Ascofaré O.; Andagalu B.; Yavo W.; Bouyou-Akotet M.; Kolapo O.; Mane K.; Worwui A.; Jeffries D.; Simpson V.; D’Alessandro U.; Kwiatkowski D.; Djimde A.A.
发表日期	2019
ISSN	0036-8075
起始页码	813
结束页码	816
卷号	365 期号:6455
英文摘要	Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite’s origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against P. falciparum malaria. © 2017 The Authors.
英文关键词	chromosome; drug resistance; genetic variation; genomics; population structure; subpopulation; Africa south of the Sahara; Article; chromosome 12; gene cluster; gene locus; genetic distance; genome; genomics; haplotype; nonhuman; parasite isolation; Plasmodium falciparum; population structure; priority journal; single nucleotide polymorphism; drug effect; drug resistance; Ethiopia; genetic selection; genetics; Ghana; human; isolation and purification; malaria falciparum; Malawi; parasitology; Plasmodium falciparum; Ethiopia; Ghana; Malawi; Plasmodium falciparum; antimalarial agent; artemisinin; artemisinin derivative; Antimalarials; Artemisinins; Drug Resistance; Ethiopia; Genetic Loci; Ghana; Haplotypes; Humans; Malaria, Falciparum; Malawi; Plasmodium falciparum; Polymorphism, Single Nucleotide; Selection, Genetic
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242820
作者单位	Medical Research Council Unit, Gambia at LSHTM, Banjul, Gambia; West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana; United States Army Medical Research Directorate-Africa, Kenya Medical Research Institute/Walter Reed Project, Kisumu, Kenya; Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, MD, United States; Wellcome Sanger Institute, Hinxton, United Kingdom; MRC Centre for Genomics and Global Health, Big Data Institute, University of Oxford, Oxford, United Kingdom; Noguchi Memorial Institute for Medical Research (NMIMR), Accra, Ghana; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia; Institut Pasteur of Madagascar, Antanarivo, Madagascar; National Institute for Medical Research (NIMR), Tanga, Tanzania; Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon; Bernhard Nocht Institute for Topical Medicine (BNITM), Hamburg, Germany; Unite des Scien...
推荐引用方式 GB/T 7714	Amambua-Ngwa A.,Amenga-Etego L.,Kamau E.,et al. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa[J],2019,365(6455).
APA	Amambua-Ngwa A..,Amenga-Etego L..,Kamau E..,Amato R..,Ghansah A..,...&Djimde A.A..(2019).Major subpopulations of Plasmodium falciparum in sub-Saharan Africa.Science,365(6455).
MLA	Amambua-Ngwa A.,et al."Major subpopulations of Plasmodium falciparum in sub-Saharan Africa".Science 365.6455(2019).