气候变化领域集成服务门户(CCPortal): The evolution and changing ecology of the African hominid oral microbiome

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DOI	10.1073/pnas.2021655118
	The evolution and changing ecology of the African hominid oral microbiome
	Yates J.A.F.; Velsko I.M.; Aron F.; Posth C.; Hofman C.A.; Austin R.M.; Parker C.E.; Mann A.E.; Nagele K.; Arthur K.W.; Arthur J.W.; Bauer C.C.; Crevecoeur I.; Cupillard C.; Curtis M.C.; Dalen L.; Bonilla M.D.-Z.; Fernandez-Lomana J.C.D.; Drucker D.G.; Escriva E.E.; Francken M.; Gibbon V.E.; Morales M.R.G.; Ana Grande Mateu; Harvati K.; Henry A.G.; Humphrey L.; Menendez M.; Mihailović D.; Peresani M.; Moroder S.R.; Roksandic M.; Rougier H.; Sazelova S.; Stock J.T.; Straus L.G.; Svoboda J.; Tesmann B.; Walker M.J.; Power R.C.; Lewis C.M.; Sankaranarayanan K.; Guschanski K.; Wrangham R.W.; Dewhirst F.E.; Salazar-Garcia D.C.; Krause J.; Herbig A.; Warinner C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:20
英文摘要	The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine-platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Dental calculus; Microbiome; Neanderthal; Primate; Salivary amylase
语种	英语
scopus关键词	alpha amylase saliva isoenzyme; starch; Africa; Alouatta; Article; biofilm; Catarrhini; chimpanzee; community structure; controlled study; diet; digestion; ecological diversity; enzyme binding; evolutionary adaptation; genetic variability; gorilla; hominid; Homo neanderthalensis; human; metagenome; mouth flora; New World howler monkey; nonhuman; Paleolithic; phylogeny; Platyrrhini; Pleistocene; species comparison; species difference; species diversity; Streptococcus
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238923
作者单位	Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig-Maximilians-University Münich, Münich, 80539, Germany; Institute for Archaeological Sciences, Eberhard Karls University of Tübingen, Tübingen, 72070, Germany; Department of Anthropology, University of Oklahoma, Norman, OK 73019, United States; Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, United States; Natural History Museum, University of Oslo, Oslo, 0562, Norway; School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, United States; Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, United States; Department of Anthropology, University of South Florida, St. Petersburg, FL 33701, United States; Palaeobiology, Biogeology, Department of G...
推荐引用方式 GB/T 7714	Yates J.A.F.,Velsko I.M.,Aron F.,et al. The evolution and changing ecology of the African hominid oral microbiome[J],2021,118(20).
APA	Yates J.A.F..,Velsko I.M..,Aron F..,Posth C..,Hofman C.A..,...&Warinner C..(2021).The evolution and changing ecology of the African hominid oral microbiome.Proceedings of the National Academy of Sciences of the United States of America,118(20).
MLA	Yates J.A.F.,et al."The evolution and changing ecology of the African hominid oral microbiome".Proceedings of the National Academy of Sciences of the United States of America 118.20(2021).