气候变化领域集成服务门户(CCPortal): Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

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DOI	10.1073/pnas.2015873118
	Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice
	Hou T.; Su W.; Duncan M.J.; Olga V.A.; Guo Z.; Gong M.C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:25
英文摘要	The quantity and quality of food intake have been considered crucial for peoples’ wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes are not fully understood. Here, we report that food intake and BP were arrhythmic in diabetic db/db mice fed a normal chow diet ad libitum. Imposing a food intake diurnal rhythm by time-restricted feeding (TRF; food was only available for 8 h during the active phase) prevented db/db mice from developing nondipping BP and effectively restored the already disrupted BP circadian rhythm in db/db mice. Interestingly, increasing the time of food availability from 8 h to 12 h during the active dark phase in db/db mice prompted isocaloric feeding and still provided robust protection of the BP circadian rhythm in db/db mice. In contrast, neither 8-h nor 12-h TRF affected BP dipping in wild-type mice. Mechanistically, we demonstrate that TRF protects the BP circadian rhythm in db/db mice via suppressing the sympathetic activity during the light phase when they are inactive and fasting. Collectively, these data reveal a potentially pivotal role of the timing of food intake in the prevention and treatment of nondipping BP in diabetes. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	blood pressure circadian rhythm; diabetes; nondipping blood pressure; sympathetic nervous system; Time-restricted feeding
语种	英语
scopus关键词	animal experiment; animal model; Article; blood pressure; blood pressure regulation; circadian rhythm; controlled study; diabetes mellitus; food intake; mouse; nondipping blood pressure; nonhuman; protection; time restricted feeding; wild type
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238888
作者单位	Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, United States; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, United States; Department of Biotatistics, University of Kentucky, Lexington, KY 40536, United States; Research and Development, Lexington Veterans Affairs Medical Center, Lexington, KY 40502, United States; Department of Physiology, University of Kentucky, Lexington, KY 40536, United States
推荐引用方式 GB/T 7714	Hou T.,Su W.,Duncan M.J.,et al. Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice[J],2021,118(25).
APA	Hou T.,Su W.,Duncan M.J.,Olga V.A.,Guo Z.,&Gong M.C..(2021).Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice.Proceedings of the National Academy of Sciences of the United States of America,118(25).
MLA	Hou T.,et al."Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice".Proceedings of the National Academy of Sciences of the United States of America 118.25(2021).