气候变化领域集成服务门户(CCPortal): Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain

CCPortal

DOI	10.1073/pnas.2100652118
	Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain
	Sel A.; Verhagen L.; Angerer K.; David R.; Klein-Flügge M.C.; Rushworth M.F.S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:37
英文摘要	The origins of oscillatory activity in the brain are currently debated, but common to many hypotheses is the notion that they reflect interactions between brain areas. Here, we examine this possibility by manipulating the strength of coupling between two human brain regions, ventral premotor cortex (PMv) and primary motor cortex (M1), and examine the impact on oscillatory activity in the motor system measurable in the electroencephalogram. We either increased or decreased the strength of coupling while holding the impact on each component area in the pathway constant. This was achieved by stimulating PMv and M1 with paired pulses of transcranial magnetic stimulation using two different patterns, only one of which increases the influence exerted by PMv over M1. While the stimulation protocols differed in their temporal patterning, they were comprised of identical numbers of pulses to M1 and PMv. We measured the impact on activity in alpha, beta, and theta bands during a motor task in which participants either made a preprepared action (Go) or withheld it (No-Go). Augmenting cortical connectivity between PMv andM1, by evoking synchronous pre- and postsynaptic activity in the PMv-M1 pathway, enhanced oscillatory beta and theta rhythms in Go and No-Go trials, respectively. Little change was observed in the alpha rhythm. By contrast, diminishing the influence of PMv over M1 decreased oscillatory beta and theta rhythms in Go and No-Go trials, respectively. This suggests that corticocortical communication frequencies in the PMv-M1 pathway can be manipulated following Hebbian spike-timing-dependent plasticity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Action control; Oscillations; Primary motor cortex; Transcranial magnetic stimulation; Ventral premotor cortex
语种	英语
scopus关键词	adult; alpha rhythm; article; brain region; controlled study; female; human; human experiment; male; oscillation; premotor cortex; primary motor cortex; spike; theta rhythm; transcranial magnetic stimulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238803
作者单位	Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, United Kingdom; Centre for Brain Science, Department of Psychology, University of Essex, Colchester, CO4 3SQ, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, 6525 HR, Netherlands
推荐引用方式 GB/T 7714	Sel A.,Verhagen L.,Angerer K.,et al. Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain[J],2021,118(37).
APA	Sel A.,Verhagen L.,Angerer K.,David R.,Klein-Flügge M.C.,&Rushworth M.F.S..(2021).Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain.Proceedings of the National Academy of Sciences of the United States of America,118(37).
MLA	Sel A.,et al."Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain".Proceedings of the National Academy of Sciences of the United States of America 118.37(2021).