气候变化领域集成服务门户(CCPortal): Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan

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DOI	10.1073/pnas.2112605118
	Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan
	Endo A.; Uchida M.; Hayashi N.; Liu Y.; Atkins K.E.; Kucharski A.J.; Funk S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:46
英文摘要	Schools play a central role in the transmission of many respiratory infections. Heterogeneous social contact patterns associated with the social structures of schools (i.e., classes/grades) are likely to influence the within-school transmission dynamics, but datadriven evidence on fine-scale transmission patterns between students has been limited. Using a mathematical model, we analyzed a large-scale dataset of seasonal influenza outbreaks in Matsumoto city, Japan, to infer social interactions within and between classes/grades from observed transmission patterns. While the relative contribution of within-class and within-grade transmissions to the reproduction number varied with the number of classes per grade, the overall within-school reproduction number, which determines the initial growth of cases and the risk of sustained transmission, was only minimally associated with class sizes and the number of classes per grade. This finding suggests that interventions that change the size and number of classes, e.g., splitting classes and staggered attendance, may have a limited effect on the control of school outbreaks. We also found that vaccination and mask-wearing of students were associated with reduced susceptibility (vaccination and mask-wearing) and infectiousness (mask-wearing), and hand washing was associated with increased susceptibility. Our results show how analysis of fine-grained transmission patterns between students can improve understanding of within-school disease dynamics and provide insights into the relative impact of different approaches to outbreak control. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Class size; Influenza; Mathematical model; School; Social network
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238751
作者单位	Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom; The Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom; The Alan Turing Institute, London, NW1 2DB, United Kingdom; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan; Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan; Graduate School of Medicine, Gunma University, Gunma, 371-8511, Japan; Simulation and Mining Division, NTT DATA Mathematical Systems Inc., Tokyo, 160-0016, Japan; Department of Mathematical and Computing Science, School of Computing, Tokyo Institute of Technology, Tokyo, 152-8552, Japan; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH16 4UX, United Kingdom
推荐引用方式 GB/T 7714	Endo A.,Uchida M.,Hayashi N.,et al. Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan[J],2021,118(46).
APA	Endo A..,Uchida M..,Hayashi N..,Liu Y..,Atkins K.E..,...&Funk S..(2021).Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan.Proceedings of the National Academy of Sciences of the United States of America,118(46).
MLA	Endo A.,et al."Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan".Proceedings of the National Academy of Sciences of the United States of America 118.46(2021).