气候变化领域集成服务门户(CCPortal): Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, “subfossil” koala lemur Megaladapis edwardsi

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DOI	10.1073/pnas.2022117118
	Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, “subfossil” koala lemur Megaladapis edwardsi
	Marciniak S.; Mughal M.R.; Godfrey L.R.; Bankoff R.J.; Randrianatoandro H.; Crowley B.E.; Bergey C.M.; Muldoon K.M.; Randrianasy J.; Raharivololona B.M.; Schuster S.C.; Malhi R.S.; Yoder A.D.; Louis E.E.; Jr.; Kistler L.; Perry G.H.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:26
英文摘要	No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal “subfossil” remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ∼160 kg) and other extraordinary Malagasy megafauna that survived into the past millennium. Yet, much about the evolutionary biology of these now-extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Thankfully, despite the challenges of DNA preservation in tropical and subtropical environments, technical advances have enabled the recovery of ancient DNA from some Malagasy subfossil specimens. Here, we present a nuclear genome sequence (∼2× coverage) for one of the largest extinct lemurs, the koala lemur Megaladapis edwardsi (∼85 kg). To support the testing of key phylogenetic and evolutionary hypotheses, we also generated high-coverage nuclear genomes for two extant lemurs, Eulemur rufifrons and Lepilemur mustelinus, and we aligned these sequences with previously published genomes for three other extant lemurs and 47 nonlemur vertebrates. Our phylogenetic results confirm that Megaladapis is most closely related to the extant Lemuridae (typified in our analysis by E. rufifrons) to the exclusion of L. mustelinus, which contradicts morphology-based phylogenies. Our evolutionary analyses identified significant convergent evolution between M. edwardsi and an extant folivore (a colobine monkey) and an herbivore (horse) in genes encoding proteins that function in plant toxin biodegradation and nutrient absorption. These results suggest that koala lemurs were highly adapted to a leaf-based diet, which may also explain their convergent craniodental morphology with the small-bodied folivore Lepilemur. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Convergent evolution; Dietary reconstruction; Megafaunal extinction; Paleogenomics; Phylogenomics
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238703
作者单位	Department of Anthropology, Pennsylvania State University, University Park, PA 16802, United States; Bioinformatics and Genomics Intercollege Graduate Program, Pennsylvania State University, University Park, PA 16082, United States; Department of Anthropology, University of Massachusetts, Amherst, MA 01003, United States; Mention Anthropobiologie et Développement Durable, Faculté des Sciences, Université d’Antananarivo, Antananarivo, 101, Madagascar; Department of Geology, University of Cincinnati, Cincinnati, OH 45220, United States; Department of Anthropology, University of Cincinnati, Cincinnati, OH 45220, United States; Department of Biology, Pennsylvania State University, University Park, PA 16802, United States; Department of Genetics, Rutgers University, New Brunswick, NJ 08854, United States; Department of Anatomy, Midwestern University, Glendale, AZ 85308, United States; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 639798, Sing...
推荐引用方式 GB/T 7714	Marciniak S.,Mughal M.R.,Godfrey L.R.,等. Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, “subfossil” koala lemur Megaladapis edwardsi[J],2021,118(26).
APA	Marciniak S..,Mughal M.R..,Godfrey L.R..,Bankoff R.J..,Randrianatoandro H..,...&Perry G.H..(2021).Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, “subfossil” koala lemur Megaladapis edwardsi.Proceedings of the National Academy of Sciences of the United States of America,118(26).
MLA	Marciniak S.,et al."Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, “subfossil” koala lemur Megaladapis edwardsi".Proceedings of the National Academy of Sciences of the United States of America 118.26(2021).