气候变化领域集成服务门户(CCPortal): Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

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DOI	10.1073/pnas.2026786118
	Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
	Yang X.; Heinemann M.; Howard J.; Huber G.; Iyer-Biswas S.; Le Treut G.; Lynch M.; Montooth K.L.; Needleman D.J.; Pigolotti S.; Rodenfels J.; Ronceray P.; Shankar S.; Tavassoly I.; Thutupalli S.; Titov D.V.; Wang J.; Foster P.J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:26
英文摘要	Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Energetic constraints; Energetic costs; Energy fluxes; Physical bioenergetics
语种	英语
scopus关键词	bioenergy; budget; cell function; cytology; energy metabolism; physics; review; article
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238505
作者单位	Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States; Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 9747 AG, Netherlands; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, United States; Theory Group, Chan Zuckerberg Biohub, San Francisco, CA 94158, United States; Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, United States; Santa Fe Institute, Santa Fe, NM 87501, United States; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287, United States; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68502, United States; Center for Computational Biology, Flatiron Institute, New York, NY 10010, United States; Biological Complexity...
推荐引用方式 GB/T 7714	Yang X.,Heinemann M.,Howard J.,et al. Physical bioenergetics: Energy fluxes, budgets, and constraints in cells[J],2021,118(26).
APA	Yang X..,Heinemann M..,Howard J..,Huber G..,Iyer-Biswas S..,...&Foster P.J..(2021).Physical bioenergetics: Energy fluxes, budgets, and constraints in cells.Proceedings of the National Academy of Sciences of the United States of America,118(26).
MLA	Yang X.,et al."Physical bioenergetics: Energy fluxes, budgets, and constraints in cells".Proceedings of the National Academy of Sciences of the United States of America 118.26(2021).