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DOI	10.1073/pnas.2105913118
	Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles
	An X.; Majumder A.; McNeely J.; Yang J.; Puri T.; He Z.; Liang T.; Snyder J.K.; Straub J.E.; Reinhard B.M.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:33
英文摘要	Lipid-coated noble metal nanoparticles (L-NPs) combine the biomimetic surface properties of a self-assembled lipid membrane with the plasmonic properties of a nanoparticle (NP) core. In this work, we investigate derivatives of cholesterol, which can be found in high concentrations in biological membranes, and other terpenoids, as tunable, synthetic platforms to functionalize L-NPs. Side chains of different length and polarity, with a terminal alkyne group as Raman label, are introduced into cholesterol and betulin frameworks. The synthesized tags are shown to coexist in two conformations in the lipid layer of the L-NPs, identified as “head-out” and “head-in” orientations, whose relative ratio is determined by their interactions with the lipid-water hydrogen-bonding network. The orientational dimorphism of the tags introduces orthogonal functionalities into the NP surface for selective targeting and plasmon-enhanced Raman sensing, which is utilized for the identification and Raman imaging of epidermal growth factor receptor-overexpressing cancer cells. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cholesterol; Epidermal growth factor; Hydrogen bonding; Lipid-coated nanoparticles; Raman spectroscopy; Surface-enhanced
语种	英语
scopus关键词	alkyne; betulin; cholesterol; lipid nanoparticle; sterol; terpenoid; Article; biomembrane; chemical labeling; chemical structure; concentration (parameter); conformation; controlled study; hydration; hydrogen bond; hydrophobicity; Raman spectrometry; reaction analysis; surface property; synthesis
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238425
作者单位	Department of Chemistry, Boston University, Boston, MA 02215, United States; The Photonics Center, Boston University, Boston, MA 02215, United States
推荐引用方式 GB/T 7714	An X.,Majumder A.,McNeely J.,et al. Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles[J],2021,118(33).
APA	An X..,Majumder A..,McNeely J..,Yang J..,Puri T..,...&Reinhard B.M..(2021).Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles.Proceedings of the National Academy of Sciences of the United States of America,118(33).
MLA	An X.,et al."Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles".Proceedings of the National Academy of Sciences of the United States of America 118.33(2021).