气候变化领域集成服务门户(CCPortal): NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning

CCPortal

DOI	10.1073/pnas.2102635118
	NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning
	Schonewille M.; Girasole A.E.; Rostaing P.; Mailhes-Hamon C.; Ayon A.; Nelson A.B.; Triller A.; Casado M.; De Zeeuw C.I.; Bouvier G.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:37
英文摘要	Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional plasticity is shaped by the balance between transcellular nitric oxide (NO) driven by presynaptic N-methyl-D-aspartate receptor (NMDAR) activation and postsynaptic calcium dynamics. However, the role and the location of NMDAR activation in these pathways is still debated in mature animals. Here, we show in adult rodents that NMDARs are present and functional in presynaptic terminals where their activation triggers NO signaling. In addition, we find that selective genetic deletion of presynaptic, but not postsynaptic, NMDARs prevents synaptic plasticity at parallel fiber-PC (PF-PC) synapses. Consistent with this finding, the selective deletion of GC NMDARs affects adaptation of the vestibulo-ocular reflex. Thus, NMDARs presynaptic to PCs are required for bidirectional synaptic plasticity and cerebellar motor learning. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cerebellum; Motor learning; Nitric oxide; Pre-NMDARs; Purkinje cells
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238388
作者单位	Department of Neuroscience, Erasmus Medical Center (MC), CA Rotterdam, NL-3000, Netherlands; Neuroscience Graduate Program, University of California, San Francisco, CA 94158, United States; Department of Neurology, University of California, San Francisco, CA 94158, United States; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94158, United States; Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, United States; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, Paris, 75005, France; CNRS, UMR 8197, Paris, 75005, France; INSERM, U 1024, Paris, 75005, France; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Sciences, Amsterdam, NL-1000 GC, Netherlands
推荐引用方式 GB/T 7714	Schonewille M.,Girasole A.E.,Rostaing P.,et al. NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning[J],2021,118(37).
APA	Schonewille M..,Girasole A.E..,Rostaing P..,Mailhes-Hamon C..,Ayon A..,...&Bouvier G..(2021).NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America,118(37).
MLA	Schonewille M.,et al."NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning".Proceedings of the National Academy of Sciences of the United States of America 118.37(2021).