气候变化领域集成服务门户(CCPortal): Market forces determine the distribution of a leaky function in a simple microbial community

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DOI	10.1073/pnas.2109813118
	Market forces determine the distribution of a leaky function in a simple microbial community
	Adkins-Jablonsky S.J.; Clark C.M.; Papoulis S.E.; Kuhl M.D.; Morris J.J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:39
英文摘要	Many biological functions are leaky, and organisms that perform them contribute some of their products to a community “marketplace” in which nonperforming individuals may compete for them. Leaky functions are partitioned unequally in microbial communities, and the evolutionary forces determining which species perform them and which become beneficiaries are poorly understood. Here, we demonstrate that the market principle of comparative advantage determines the distribution of a leaky antibiotic resistance gene in an environment occupied by two “species”—strains of Escherichia coli growing on mutually exclusive resources and thus occupying separate niches. Communities comprised of antibiotic-resistant cells were rapidly invaded by sensitive cells of both types. While the two phenotypes coexisted stably for 500 generations, in 15/18 replicates, antibiotic sensitivity became fixed in one species. Fixation always occurred in the same species despite both species being genetically identical except for their niche-defining mutation. In the absence of antibiotic, the fitness cost of resistance was identical in both species. However, the intrinsic resistance of the species that ultimately became the sole helper was significantly lower, and thus its reward for expressing the resistance gene was higher. Opportunity cost of resistance, not absolute cost or efficiency of antibiotic removal, determined which species became the helper, consistent with the economic theory of comparative advantage. We present a model that suggests that this market-like dynamic is a general property of Black Queen systems and, in communities dependent on multiple leaky functions, could lead to the spontaneous development of an equitable and efficient division of labor. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Black Queen hypothesis; Comparative advantage; Ecological species concept
语种	英语
scopus关键词	antibiotic resistance; Article; bacterial cell; bacterial gene; bacterial strain; bacterium culture; controlled study; Escherichia coli; leaky function; microbial community; microbiological phenomena and functions; nonhuman; phenotype; species distribution; species invasion; antibiotic resistance; drug effect; evolution; microflora; physiology; theoretical model; antiinfective agent; Anti-Bacterial Agents; Biological Evolution; Drug Resistance, Microbial; Escherichia coli; Microbiota; Models, Theoretical
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238367
作者单位	Department of Biology, University of Alabama at Birmingham, AL, Birmingham, 35294, United Kingdom; BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, MI 48824, United States; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, United States; Department of Microbiology, University of Tennessee, Knoxville, TN 37996, United States
推荐引用方式 GB/T 7714	Adkins-Jablonsky S.J.,Clark C.M.,Papoulis S.E.,et al. Market forces determine the distribution of a leaky function in a simple microbial community[J],2021,118(39).
APA	Adkins-Jablonsky S.J.,Clark C.M.,Papoulis S.E.,Kuhl M.D.,&Morris J.J..(2021).Market forces determine the distribution of a leaky function in a simple microbial community.Proceedings of the National Academy of Sciences of the United States of America,118(39).
MLA	Adkins-Jablonsky S.J.,et al."Market forces determine the distribution of a leaky function in a simple microbial community".Proceedings of the National Academy of Sciences of the United States of America 118.39(2021).