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| NSF Postdoctoral Fellowship in Biology FY 2021: Leveraging rapid evolution to study the dynamics of polygenic adaptation | |
| 项目编号 | 2109407 |
| Mark Bitter | |
| 项目主持机构 | Bitter, Mark Christopher |
| 开始日期 | 2021-07-01 |
| 结束日期 | 06/30/2023 |
| 英文摘要 | This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2021, Integrative Research Investigating the Rules of Life Governing Interactions Between Genomes, Environment and Phenotypes. The fellowship supports research and training of the fellow that will contribute to the area of Rules of Life in innovative ways. The fellow will conduct research focusing on polygenic traits, which are defined as the physical characteristics, or phenotypes, of an organism that are influenced by many genes located throughout an individual’s genome. Examples of polygenic traits include numerous human diseases and the resilience of coral reefs to global climate change. The fellow will conduct experiments to understand: (1) how genetic differences between individuals give rise to differences in the physical expression of polygenic traits and (2) how polygenic traits evolve in natural populations. Through this, the fellow largely aims to lend insight into the extent to which genetic information can be used to accurately predict an individual’s phenotype. Throughout the duration of this fellowship, the fellow will engage in outreach efforts that specifically aim to increase the participation of underrepresented groups in evolutionary biology. To resolve the genetic basis and evolutionary dynamics of polygenic traits, the fellow will study populations of Drosophila melanogaster as they rapidly evolve in response to seasonal fluctuations in the environment. This system provides a lens to directly observe evolution and selection, both on individual genes and specific polygenic traits throughout the course of adaptation. This work will focus on three polygenic traits in D. melanogaster with demonstrated ecological relevance in natural populations. The first aim of the fellow’s research will involve mapping the genetic basis of each trait as it rapidly evolves between seasons. Through this, the fellow aims to determine whether the genotype-to-phenotype map is stable during evolution, or whether the genetic basis of polygenic traits is altered by the evolutionary process. The second aim will leverage these results, in combination with 7 years of existing data, to explore the extent to which those genetic polymorphisms that underpin the phenotypic variation of a polygenic trait are the same as those that respond to natural selection and drive the evolution of the trait through time. The fellow will further gain extensive formal and informal training in preparation for a career of academic research and teaching. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. |
| 资助机构 | US-NSF |
| 项目经费 | $138,000.00 |
| 项目类型 | Fellowship Award |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/212254 |
| 推荐引用方式 GB/T 7714 | Mark Bitter.NSF Postdoctoral Fellowship in Biology FY 2021: Leveraging rapid evolution to study the dynamics of polygenic adaptation.2021. |
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