Climate Change Data Portal
| ECA-PGR: Developing multiplexed transcriptional regulation systems for plant genome reprogramming | |
| 项目编号 | 1758745 |
| Yiping Qi | |
| 项目主持机构 | University of Maryland, College Park |
| 开始日期 | 2018-09-01 |
| 结束日期 | 08/31/2023 |
| 英文摘要 | Altering gene regulation, also known as transcriptional reprogramming, is at the heart of plant development, reproduction, and responses to various stresses. Simultaneously reprogramming multiple, specific genes is desirable for studying gene function and expression, dissecting complex signaling networks, engineering metabolic pathways, and building synthetic switches and circuits. However, genetic tools that would allow biologists to turn multiple genes on and off in this way in plant cells are currently unavailable. This project develops these tools and will not only aid basic research in plant science, but also allow plant scientists to seek novel solutions to global challenges such as devastating plant diseases, economical bioenergy production, sustainable agriculture and response to climate change. This project applies recent technical advances in CRISPR plant genome engineering to build essential comprehensive genome reprogramming tools and demonstrate them in rice, an important crop. The specific aims of this project are to develop 1) an efficient multiplexed transcriptional activation system; 2) an efficient multiplexed transcriptional repression system; 3) a bidirectional multiplexed transcriptional regulation system; and 4) a CRISPR design tool within the software of the Integrated Genome Browser for transcriptional regulation in plants. The highly efficient plant transcriptional reprogramming systems and the design tool developed in this project will benefit the plant research community in advancing basic research and crop improvement. These easy-to-use, effective tool packages will be tested for sophisticated multigene, transcriptional reprogramming and made available to researchers at the public repository, Addgene. In addition, the project will provide cutting-edge training to a diverse group of students at various levels, including a postdoctoral scientist, two PhD students, and many undergraduate and high school students from diverse backgrounds. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. |
| 资助机构 | US-NSF |
| 项目经费 | $930,584.00 |
| 项目类型 | Continuing Grant |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/212135 |
| 推荐引用方式 GB/T 7714 | Yiping Qi.ECA-PGR: Developing multiplexed transcriptional regulation systems for plant genome reprogramming.2018. |
| 条目包含的文件 | 条目无相关文件。 | |||||
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Yiping Qi]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Yiping Qi]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Yiping Qi]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
