气候变化领域集成服务门户(CCPortal): Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression

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DOI	10.1016/j.scib.2020.11.003
	Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression
	Xian H.; Huang W.; Sun T.; Yang S.; Zhang C.; Wang J.; Zhang Y.; Cui J.
发表日期	2021
ISSN	20959273
起始页码	794
结束页码	802
卷号	66 期号:8
英文摘要	Ubiquitination plays a crucial role in retinoic acid-inducible gene I (RIG-I)-induced antiviral responses. However, the precise regulatory mechanisms of RIG-I activity mediated by conjugated and unanchored ubiquitin chains remain to be determined. In this study, we discovered that T55 of RIG-I was required for its binding ability for the unanchored ubiquitin chains. Experimental and mathematical analysis showed that unanchored ubiquitin chains associated with RIG-I were essential for sustained activation of type I interferon (IFN) signaling. Transcriptomics study revealed that the binding of RIG-I with unanchored ubiquitin chains additionally regulated the expression of a subset of metabolic and cell fate decision genes. Moreover, we found that ubiquitin-specific peptidase 21 (USP21) and USP3 deubiquitinate conjugated and unanchored ubiquitin chains on RIG-I respectively. Taken together, characterization of the regulation mode and functions of conjugated ubiquitination and the unconjugated ubiquitin chain-binding of RIG-I may provide means to fine-tune RIG-I-mediated type I IFN signaling. © 2020 Science China Press
关键词	Antiviral immunity Cellular homeostasis RIG-I Type I interferon Ubiquitination Unanchored ubiquitin chains
英文关键词	Antibiotics; Chemical activation; Gene expression; Glycoproteins; Antiviral response; Binding abilities; Cell fate decision; Induced interferons; Mathematical analysis; Regulatory mechanism; Sustained activation; Type i interferons; Activation analysis
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207616
作者单位	MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China; Department of Gastroenterology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China; School of Life Sciences, Anqing Normal University, Anqing, 246133, China
推荐引用方式 GB/T 7714	Xian H.,Huang W.,Sun T.,et al. Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression[J],2021,66(8).
APA	Xian H..,Huang W..,Sun T..,Yang S..,Zhang C..,...&Cui J..(2021).Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression.Science Bulletin,66(8).
MLA	Xian H.,et al."Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression".Science Bulletin 66.8(2021).