气候变化领域集成服务门户(CCPortal): On-demand degradable magnetic resonance imaging nanoprobes

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DOI	10.1016/j.scib.2020.10.020
	On-demand degradable magnetic resonance imaging nanoprobes
	Sun W.; Wang Z.; Liu J.; Jiang C.; Chen W.; Yu B.; Wang W.; Lu L.
发表日期	2021
ISSN	20959273
起始页码	676
结束页码	684
卷号	66 期号:7
英文摘要	Theranostic nanoprobes can potentially integrate imaging and therapeutic capabilities into a single platform, offering a new personalized cancer diagnostic tool. However, there is a growing concern that their clinical application is not safe, particularly due to metal-containing elements, such as the gadolinium used in magnetic resonance imaging (MRI). We demonstrate for the first time that the photothermal melting of the DNA duplex helix was a reliable and versatile strategy that enables the on-demand degradation of the gadolinium-containing MRI reporter gene from polydopamine (PDA)-based theranostic nanoprobes. The combination of chemotherapy (doxorubicin) and photothermal therapy, which leads to the enhanced anti-tumor effect. In vivo MRI tracking reveals that renal filtration was able to rapidly clear the free gadolinium-containing MRI reporter from the mice body. This results in a decrease in the long-term toxic effect of theranostic MRI nanoprobes. Our findings may pave the way to address toxicity issues of the theranostic nanoprobes. © 2020 Science China Press
关键词	DNA-based MRI reporter On-demand degradation Photothermal melting Theranostic nanoprobes
英文关键词	Chemotherapy; Diagnosis; Gadolinium; Mammals; Nanoprobes; Theranostics; Antitumor effect; Cancer diagnostics; Clinical application; MRI reporter genes; Photothermal melting; Photothermal therapy; Polydopamine; Single platform; Magnetic resonance imaging
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207562
作者单位	College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Instrumental Analysis Center of Qingdao University, Qingdao University, Qingdao, 266071, China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Department of Radiology, Second Hospital of Jilin University, Changchun, 130041, China
推荐引用方式 GB/T 7714	Sun W.,Wang Z.,Liu J.,et al. On-demand degradable magnetic resonance imaging nanoprobes[J],2021,66(7).
APA	Sun W..,Wang Z..,Liu J..,Jiang C..,Chen W..,...&Lu L..(2021).On-demand degradable magnetic resonance imaging nanoprobes.Science Bulletin,66(7).
MLA	Sun W.,et al."On-demand degradable magnetic resonance imaging nanoprobes".Science Bulletin 66.7(2021).