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DOI	10.1016/j.scib.2021.01.032
	Schizophrenia: a classic battle ground of nature versus nurture debate
	St Clair D.; Lang B.
发表日期	2021
ISSN	20959273
起始页码	1037
结束页码	1046
卷号	66 期号:10
英文摘要	Much has been learned about the etiology and pathogenesis of schizophrenia since the term was first used by Eugene Bleuler over a century ago to describe one of the most important forms of major mental illness to affect mankind. Both nature and nurture feature prominently in our understanding of the genesis of the overall risk of developing schizophrenia. We now have a firm grasp of the broad structure of the genetic architecture and several key environmental risk factors have been identified and delineated. However, much of the heritability of schizophrenia remains unexplained and the reported environmental risk factors do not explain all the variances not attributable to genetic risk factors. The biggest problem at present is that our understanding of the causal mechanisms involved is still in its infancy. In this review, we describe the extent and limits of our knowledge of the specific genetic/constitutional and non-genetic/environmental factors that contribute to the overall risk of schizophrenia. We suggest novel methods may be required to understand the almost certainly immensely complex multi-level causal mechanisms that contribute to the generation of the schizophrenia phenotype. © 2021 Science China Press
关键词	Nature Nurture Omnigenic Schizophrenia
英文关键词	Environmental risk factor; Genetic architecture; Genetic risks; Mental illness; Multilevels; Novel methods; Diseases
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207556
作者单位	Department of Psychiatry, The Second Xiangya Hospital, Central South University, National Clinical Research Center for Mental Disorders, Changsha, 410011, China; Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom; Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China
推荐引用方式 GB/T 7714	St Clair D.,Lang B.. Schizophrenia: a classic battle ground of nature versus nurture debate[J],2021,66(10).
APA	St Clair D.,&Lang B..(2021).Schizophrenia: a classic battle ground of nature versus nurture debate.Science Bulletin,66(10).
MLA	St Clair D.,et al."Schizophrenia: a classic battle ground of nature versus nurture debate".Science Bulletin 66.10(2021).