气候变化领域集成服务门户(CCPortal): LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia

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DOI	10.1016/j.scib.2021.01.026
	LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia
	Shi L.-N.; Zhou Y.; Wu C.; Huang W.; Yuan F.; Chen J.; Wu Z.; Tu W.; Chen H.; Chen Q.; Zhu M.; Peng H.; Yang Y.; Tang H.
发表日期	2021
ISSN	20959273
英文摘要	CD1d-restricted natural killer T (NKT) cells are innate-like T lymphocytes with protective or pathogenic roles in the development of influenza pneumonia. Here, we show that lung-infiltrated and activated NKT cells are the major cellular source of LIGHT/TNFSF14, which determines the severity of pulmonary pneumonia by highly deteriorative influenza A virus (IAV) infection. Compared to wild-type mice, LIGHT−/− mice exhibit much lower morbidity and mortality to IAV, due to alleviated lung damage and reduced apoptosis of alveolar macrophages (AMs). LIGHT preferentially promotes cell death of lymphotoxin β receptors positive (LTβR+) AMs but not herpesvirus entry mediator positive (HVEM+) AMs. Therefore, these results suggest that NKT-derived LIGHT augments cell death of the tissue protective AMs in exacerbating lung pathology and susceptibility to fatal influenza infection. Suppression of LIGHT signaling might be a viable option in the treatment of influenza-associated acute respiratory distress syndrome. © 2021 Science China Press
关键词	Alveolar macrophages Influenza A virus LIGHT/TNFSF14 Natural killer T cells
英文关键词	Biological organs; Cell death; Macrophages; Mammals; T-cells; Tissue; Alveolar macrophages; Cell-be; Cell/B.E; Cell/BE; Cellulars; Influenza A virus; LIGHT/TNFSF14; Natural killer T cell; Pathogenics; T lymphocytes; Viruses
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207550
作者单位	CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; Department of Infectious Disease, Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Center for Public Health Research and State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing, 210093, China; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, Hong Kong; The Pateurien College, Soochow University, Suzhou, 215006, China; The Graduate School of University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式 GB/T 7714	Shi L.-N.,Zhou Y.,Wu C.,et al. LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia[J],2021.
APA	Shi L.-N..,Zhou Y..,Wu C..,Huang W..,Yuan F..,...&Tang H..(2021).LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia.Science Bulletin.
MLA	Shi L.-N.,et al."LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia".Science Bulletin (2021).