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DOI	10.1016/j.scib.2020.12.027
	Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6
	Jin L.; Cao L.; Zhu Y.; Cao J.; Li X.; Zhou J.; Liu B.; Zhao T.
发表日期	2021
ISSN	20959273
起始页码	803
结束页码	812
卷号	66 期号:8
英文摘要	Chimeric antigen receptor-T (CAR-T) cells have limited therapeutic efficacy against solid tumors, partially due to their limited ability to reach and invade into the neoplastic foci. By gene expression profiling interactive analysis, we identified that the C–C motif chemokine ligand (CCL) 20 is highly expressed in lung and other most incidence and/or mortality cancers such as colon, rectum, stomach, and liver cancers. Forced expression of C–C motif chemokine receptor 6 (CCR6), the biunique receptor of CCL20, results in robust trafficking of CAR-T cells toward CCL20-secreting tumor cells. In a lung cancer xenograft mouse model, CCR6-expressing CAR-T cells efficiently migrate to and infiltrate into solid tumors upon infusion, leading to effective tumor clearance and significantly prolonged survival of tumor-bearing mice. In addition, culturing CCR6-CAR-T cells with interleukin (IL)-7 and IL-15 further improved their anti-lung cancer activity. Our findings provide supporting evidence for the clinical development of chemokine receptor-engineered CAR-T cells for solid tumor immunotherapy. © 2020 Science China Press
关键词	CAR-T CCL20 CCR6 Lung cancer Migration
英文关键词	Antigens; Biological organs; Diseases; Gene expression; Mammals; T-cells; Tumors; Antigen receptors; Chemokine ligands; Chemokine receptors; Clinical development; Ectopic expressions; Gene expression profiling; Interactive analysis; Therapeutic efficacy; Cytology
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207447
作者单位	State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China; State Key Laboratory of Proteomics, Translational Medicine Center of Stem Cells, 307-Ivy Translational Medicine Center, Laboratory of Oncology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, 100071, China
推荐引用方式 GB/T 7714	Jin L.,Cao L.,Zhu Y.,等. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6[J],2021,66(8).
APA	Jin L..,Cao L..,Zhu Y..,Cao J..,Li X..,...&Zhao T..(2021).Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6.Science Bulletin,66(8).
MLA	Jin L.,et al."Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6".Science Bulletin 66.8(2021).