气候变化领域集成服务门户(CCPortal): Binding of the SARS-CoV-2 spike protein to glycans

CCPortal

DOI	10.1016/j.scib.2021.01.010
	Binding of the SARS-CoV-2 spike protein to glycans
	Hao W.; Ma B.; Li Z.; Wang X.; Gao X.; Li Y.; Qin B.; Shang S.; Cui S.; Tan Z.
发表日期	2021
ISSN	20959273
起始页码	1205
结束页码	1214
卷号	66 期号:12
英文摘要	The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing glycolipids/glycoproteins. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2, SARS-CoV, and Middle East respiratory disease (MERS)-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses. © 2021 Science China Press
关键词	Glycan microarray Heparan sulfate SARS-CoV-2 S protein Sialic acid Sulfation Surface plasmon resonance
英文关键词	Antiviral agents; Carboxylic acids; Cell membranes; Polysaccharides; Proteins; Sulfur compounds; Viruses; Cell surfaces; Glycan microarrays; Glycans; Heparan sulphate; Host cells; SARS-CoV-2 S protein; Sialic acids; Spike protein; Sulphation; Surface-plasmon resonance; Surface plasmon resonance
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207418
作者单位	NHC Key Laboratory of Systems Biology of Pathogens, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO 80303, United States; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China
推荐引用方式 GB/T 7714	Hao W.,Ma B.,Li Z.,et al. Binding of the SARS-CoV-2 spike protein to glycans[J],2021,66(12).
APA	Hao W..,Ma B..,Li Z..,Wang X..,Gao X..,...&Tan Z..(2021).Binding of the SARS-CoV-2 spike protein to glycans.Science Bulletin,66(12).
MLA	Hao W.,et al."Binding of the SARS-CoV-2 spike protein to glycans".Science Bulletin 66.12(2021).