气候变化领域集成服务门户(CCPortal): Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding

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DOI	10.1016/j.scib.2020.03.025
	Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding
	Zhang Z.; Zhai Q.; Gu Y.; Zhang T.; Huang Z.; Liu Z.; Liu Y.; Xu Y.
发表日期	2020
ISSN	20959273
起始页码	1268
结束页码	1280
卷号	65 期号:15
英文摘要	The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-restricted feeding (TRF) has potential as a preventative or therapeutic approach against many diseases. The potential side effects of TRF remain unknown. Here we show that daily 4-h TRF treatment in mice can severely impair body temperature homeostasis and can result in lethality. Nearly half of the mice died at 21 °C, and all mice died at 18 °C during 4-h TRF. This effect was modulated by the circadian clock and was associated with severe hypothermia due to loss of body temperature homeostasis. Remarkably, disrupting the circadian clock by SCN lesions or constant light rescued lethality during TRF. Analysis of circadian gene expression in the dorsomedial hypothalamus (DMH) demonstrated that TRF reprograms rhythmic transcriptome in DMH and suppresses expression of genes, such as Ccr5 and Calcrl, which are involved in thermoregulation. Together, our results demonstrated a potent effect of TRF on body temperature homeostasis and the role of SCN function in this process. Our results further suggested that circadian arrhythmicity can have potential beneficial effects under certain stress conditions. © 2020 Science China Press
关键词	Body temperature Circadian clock Hypothermia The dorsomedial hypothalamus The suprachiasmatic nucleus Time-restricted feeding
英文关键词	Clocks; Gene expression; Mammals; Beneficial effects; Body temperature; Circadian clock; Constant light; Side effect; Stress condition; Suprachiasmatic nucleus; Transcriptomes; Physiology
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207317
作者单位	Model Animal Research Center, Nanjing University, Nanjing, 210061, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou, 215123, China; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China
推荐引用方式 GB/T 7714	Zhang Z.,Zhai Q.,Gu Y.,et al. Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding[J],2020,65(15).
APA	Zhang Z..,Zhai Q..,Gu Y..,Zhang T..,Huang Z..,...&Xu Y..(2020).Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding.Science Bulletin,65(15).
MLA	Zhang Z.,et al."Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding".Science Bulletin 65.15(2020).