气候变化领域集成服务门户(CCPortal): Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis

CCPortal

DOI	10.1016/j.scib.2020.03.028
	Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis
	Wang X.; Zhang Y.; Wang X.; Dai J.; Hua R.; Zeng S.; Li H.
发表日期	2020
ISSN	20959273
起始页码	1203
结束页码	1216
卷号	65 期号:14
英文摘要	The bed nucleus of the stria terminalis (BNST) plays a critical role in regulating anxiety, yet the involved specific cell types and their connections functioning in anxiety-related behaviors remains elusive. Here we identified two cell subpopulations—corticotropin-releasing hormone-positive (CRH+) and protein kinase C-δ-positive (PKC-δ+) neurons—each displayed discrete emotionally valenced behaviors in the anterior-dorsal BNST (adBNST). Using whole-cell patch-clamp recordings and virus-assisted circuit tracing techniques, we delineated the local and long-range connectivity networks in a cell-type-specific manner. The results show that the CRH+ and PKC-δ+ neurons received inputs from similar brain regions and exhibited significant differences in the downstream projection density. In addition, in vivo calcium imaging as well as gain- and loss-of-function studies characterized the physiological response properties and the functional heterogeneities in modulating anxiety, further suggesting the similarity and individuality between the two adBNST cell types. These results provide novel insights into the circuit architecture of adBNST neurons underlying the functionally specific neural pathways that relate to anxiety disorders. © 2020 Science China Press
关键词	Anterior-dorsal BNST Anxiety CRH PKC-δ
英文关键词	Brain; Computer viruses; Cytology; Electrophysiology; Neurons; Physiological models; Timing circuits; Viruses; Anterior-dorsal BNST; Anxiety; Corticotropin-releasing hormone; Functional heterogeneity; Long-range connectivities; Physiological response; Protein kinase c deltas; Whole cell patch clamp; Cells
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207219
作者单位	Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China; Ministry of Education Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, 430074, China
推荐引用方式 GB/T 7714	Wang X.,Zhang Y.,Wang X.,et al. Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis[J],2020,65(14).
APA	Wang X..,Zhang Y..,Wang X..,Dai J..,Hua R..,...&Li H..(2020).Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis.Science Bulletin,65(14).
MLA	Wang X.,et al."Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis".Science Bulletin 65.14(2020).