气候变化领域集成服务门户(CCPortal): Sedentary behavior and risk of incident cardiovascular disease among Chinese adults

CCPortal

DOI	10.1016/j.scib.2020.05.029
	Sedentary behavior and risk of incident cardiovascular disease among Chinese adults
	Liu Q.; Liu F.; Li J.; Huang K.; Yang X.; Chen J.; Liu X.; Cao J.; Shen C.; Yu L.; Zhao Y.; Wu X.; Zhao L.; Li Y.; Hu D.; Lu X.; Huang J.; Gu D.
发表日期	2020
ISSN	20959273
起始页码	1760
结束页码	1766
卷号	65 期号:20
英文摘要	Although emerging studies from high-income countries investigated the relationship between sedentary behavior (SB) and cardiovascular risk, little evidence came from developing countries. Moreover, the benefits of reallocating time from SB to physical activity (PA) on incident cardiovascular disease (CVD) are unknown. Using three cohorts from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project, we included 93 110 adults who were free from CVD at baseline. Cox proportional hazards models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD, including stroke, coronary heart disease, and CVD death. Isotemporal substitution models were applied to estimate the per-hour effects of replacing SB with PA. After 5.8 years follow-up, 3799 CVD cases were identified. A gradient positive association between sedentary time and incident CVD was observed. Relative to those with < 5 h/d sedentary time, the multivariable-adjusted HRs (95% CIs) of CVD incidence were 1.07(0.96–1.20), 1.27(1.13–1.43) and 1.51(1.34–1.70) for those having 5–<8, 8–<10, and ≥ 10 h/d sedentary time, respectively. When participants were cross-classified by SB and moderate to vigorous physical activity (MVPA) level, the CVD risk was highest in those with ≥ 10 h/d SB and < 150 min/week MVPA. Among those who reported ≥ 5 h/d sedentary time, per-hour substitution of SB with light, moderate, and vigorous PA reduced incident CVD risk by 5%, 6%, and 8%, respectively. The study first found that sedentary time was associated with increased incident CVD risk among Chinese adults and that substitution of SB with PA of any intensity could convey cardiovascular benefits among those with ≥ 5 h/d SB. © 2020 Science China Press
关键词	Cardiovascular disease Cohort study Sedentary behavior
英文关键词	Cardiology; Developing countries; Hazards; Cardio-vascular disease; Cardiovascular risk; Confidence interval; Coronary heart disease; Cox proportional hazards models; Multi variables; Physical activity; Substitution models; Diseases
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207132
作者单位	Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China; Division of Epidemiology, Guangdong Provincial People's Hospital and Cardiovascular Institute, Guangzhou, 510080, China; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Department of Cardiology, Fujian Provincial Hospital, Fuzhou, 350014, China; Shandong First Medical University, Jinan, 271099, China; Sichuan Center for Disease Control and Prevention, Chengdu, 610041, China; Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, 518071, China; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; School of Med...
推荐引用方式 GB/T 7714	Liu Q.,Liu F.,Li J.,et al. Sedentary behavior and risk of incident cardiovascular disease among Chinese adults[J],2020,65(20).
APA	Liu Q..,Liu F..,Li J..,Huang K..,Yang X..,...&Gu D..(2020).Sedentary behavior and risk of incident cardiovascular disease among Chinese adults.Science Bulletin,65(20).
MLA	Liu Q.,et al."Sedentary behavior and risk of incident cardiovascular disease among Chinese adults".Science Bulletin 65.20(2020).