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| Structural basis of the polar tube invasion machinery from microsporidia parasites | |
| 项目编号 | 1R01AI147131-01A1 |
| BHABHA, GIRA | |
| 项目主持机构 | NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
| 开始日期 | 2020-03-01 |
| 结束日期 | 2025-02-28 |
| 英文摘要 | Project Narrative Microsporidia are unicellular, ?fungal? parasites with a wide host-range, from insects to humans; ?they are emerging pathogens, classified as NIAID Category B opportunistic pathogens, and cause microsporidiosis in immunocompromised patients.? To gain entry into a target cell, microsporidia employ a remarkably unique and specialized harpoon-like invasion machine called the polar tube, which is conserved among microsporidial species. Here we will focus on understanding the mechanism by which microsporidial parasites use this unique organelle to initiate infection, which may provide broader insights into infection mechanisms used by other eukaryotic parasites. |
| 英文关键词 | 3-Dimensional; Acquired Immunodeficiency Syndrome; Address; Animals; Architecture; base; Bees; Biochemical; Biochemistry; Biological Assay; Biology; Biophysics; Bombyx; burden of illness; Categories; Cells; Cellular biology; Cellular Structures; Cilia; Complex; Cryo-electron tomography; Cryoelectron Microscopy; Data; Disease; electron tomography; Encephalitozoon cuniculi; Encephalitozoon hellem; Environment; experimental study; Face; Farming environment; Fishes; Fluorescent Dyes; Freezing; genetic manipulation; Growth; Honey; Human; human pathogen; Image; Immunocompromised Host; In Situ; In Vitro; in vivo; Individual; Infection; Insecta; insight; Ions; Light; light microscopy; lightspeed; Mass Spectrum Analysis; Microscopy; Microsporidia; Microsporidiosis; Microtubules; Modernization; Molecular Conformation; Molecular Structure; mortality; Movement; Names; National Institute of Allergy and Infectious Disease; Optics; Organ Transplantation; Organelles; Parasites; Parasitic infection; particle; pathogen; Patients; Process; protein complex; protein protein interaction; Protein Subunits; Proteins; Proteome; reconstruction; Reproduction spores; Resolution; Sampling; Scanning Electron Microscopy; Sequence Homology; Side; Speed; structural biology; Structure; Techniques; Thinness; Transplant Recipients; Tube; Work; X-Ray Crystallography; |
| 学科分类 | 14 - 医学科学 |
| 资助机构 | US-NIH |
| 项目经费 | 648532 |
| 项目类型 | Non-SBIR/STTR RPGs |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/191269 |
| 推荐引用方式 GB/T 7714 | BHABHA, GIRA.Structural basis of the polar tube invasion machinery from microsporidia parasites.2020. |
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