气候变化领域集成服务门户(CCPortal): Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes

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DOI	10.1073/PNAS.2017401118
	Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes
	Waterstraat G.; Körber R.; Storm J.-H.; Curio G.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Neuronal spiking is commonly recorded by invasive sharp micro-electrodes, whereas standard noninvasive macroapproaches (e.g., electroencephalography [EEG] and magnetoencephalography [MEG]) predominantly represent mass postsynaptic potentials. A notable exception are low-amplitude high-frequency (∼600 Hz) somatosensory EEG/MEG responses that can represent population spikes when averaged over hundreds of trials to raise the signal-to-noise ratio. Here, a recent leap in MEG technology-featuring a factor 10 reduction in white noise level compared with standard systems-is leveraged to establish an effective single-trial portrayal of evoked cortical population spike bursts in healthy human subjects. This time-resolved approach proved instrumental in revealing a significant trial-to-trial variability of burst amplitudes as well as time-correlated (∼10 s) fluctuations of burst response latencies. Thus, ultralow-noise MEG enables noninvasive single-trial analyses of human cortical population spikes concurrent with low-frequency mass postsynaptic activity and thereby could comprehensively characterize cortical processing, potentially also in diseases not amenable to invasive microelectrode recordings. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	High-frequency somatosensory evoked responses; Magnetoencephalography; Noninvasive; Single-trial analysis; Spiking activity
语种	英语
scopus关键词	adult; amplitude modulation; Article; cohort analysis; controlled study; electroencephalogram; electromagnetism; evoked response; human; human experiment; magnetoencephalography; male; middle aged; neocortex; non invasive procedure; normal human; postsynaptic potential; priority journal; resting state network; spiking neural network; time resolved spectroscopy
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181180
作者单位	Neurophysics Group, Department of Neurology, Charit-Universitätsmedizin Berlin, Berlin, 12203, Germany; Department of Biosignals, Physikalisch-Technische Bundesanstalt, Berlin, 10587, Germany; Bernstein Center for Computational Neuroscience, Berlin, 10115, Germany
推荐引用方式 GB/T 7714	Waterstraat G.,Körber R.,Storm J.-H.,et al. Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes[J],2021,118(11).
APA	Waterstraat G.,Körber R.,Storm J.-H.,&Curio G..(2021).Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Waterstraat G.,et al."Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).