气候变化领域集成服务门户(CCPortal): Social isolation uncovers a circuit underlying context-dependent territory-covering micturition

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DOI	10.1073/pnas.2018078118
	Social isolation uncovers a circuit underlying context-dependent territory-covering micturition
	Hyun M.; Taranda J.; Radeljic G.; Miner L.; Wang W.; Ochandarena N.; Huang K.W.; Osten P.; Sabatini B.L.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal cord via the pontine micturition center (PMC). Here, we exploited a behavioral paradigm in which mice, depending on strain, social experience, and sensory context, either vigorously cover an arena with small urine spots or deposit urine in a few isolated large spots. We refer to these micturition modes as, respectively, high and low territory-covering micturition (TCM) and find that the presence of a urine stimulus robustly induces high TCM in socially isolated mice. Comparison of the brain networks activated by social isolation and by urine stimuli to those upstream of the PMC identified the lateral hypothalamic area as a potential modulator of micturition modes. Indeed, chemogenetic manipulations of the lateral hypothalamus can switch micturition behavior between high and low TCM, overriding the influence of social experience and sensory context. Our results suggest that both inhibitory and excitatory signals arising from a network upstream of the PMC are integrated to determine context- and social-experience-dependent micturition patterns. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Hypothamaus; Micturition; Pons; Social hierarchy
语种	英语
scopus关键词	animal experiment; animal tissue; article; Barrington nucleus; human; lateral hypothalamus; male; mouse; nerve cell network; nonhuman; social hierarchy; social isolation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181154
作者单位	Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, United States; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, United States
推荐引用方式 GB/T 7714	Hyun M.,Taranda J.,Radeljic G.,et al. Social isolation uncovers a circuit underlying context-dependent territory-covering micturition[J],2021,118(1).
APA	Hyun M..,Taranda J..,Radeljic G..,Miner L..,Wang W..,...&Sabatini B.L..(2021).Social isolation uncovers a circuit underlying context-dependent territory-covering micturition.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Hyun M.,et al."Social isolation uncovers a circuit underlying context-dependent territory-covering micturition".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).