气候变化领域集成服务门户(CCPortal): Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology

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DOI	10.1073/pnas.2018112118
	Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology
	White M.A.; Bonfini A.; Wolfner M.F.; Buchon N.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Drosophila melanogaster females experience a large shift in energy homeostasis after mating to compensate for nutrient investment in egg production. To cope with this change in metabolism, mated females undergo widespread physiological and behavioral changes, including increased food intake and altered digestive processes. The mechanisms by which the female digestive system responds to mating remain poorly characterized. Here, we demonstrate that the seminal fluid protein Sex Peptide (SP) is a key modulator of female post-mating midgut growth and gene expression. SP is both necessary and sufficient to trigger post-mating midgut growth in females under normal nutrient conditions, and likely acting via its receptor, Sex Peptide Receptor (SPR). Moreover, SP is responsible for almost the totality of midgut transcriptomic changes following mating, including up-regulation of protein and lipid metabolism genes and down-regulation of carbohydrate metabolism genes. These changes in metabolism may help supply the female with the nutrients required to sustain egg production. Thus, we report a role for SP in altering female physiology to enhance reproductive output: Namely, SP triggers the switch from virgin to mated midgut state. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Digestive tract; Drosophila post-mating response; Gut growth; Sex peptide; Transcriptome
语种	英语
scopus关键词	peptide; sex peptide; transcriptome; unclassified drug; adult; Article; carbohydrate metabolism; controlled study; down regulation; Drosophila melanogaster; female; gene expression; genotype; lipid metabolism; male; mating; midgut; nonhuman; priority journal; transcriptomics; upregulation; wild type
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181151
作者单位	Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States; Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY 14853, United States; Department of Entomology, Cornell University, Ithaca, NY 14853, United States
推荐引用方式 GB/T 7714	White M.A.,Bonfini A.,Wolfner M.F.,et al. Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology[J],2021,118(1).
APA	White M.A.,Bonfini A.,Wolfner M.F.,&Buchon N..(2021).Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	White M.A.,et al."Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).