气候变化领域集成服务门户(CCPortal): Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration

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DOI	10.1073/pnas.2012482118
	Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration
	Ishii S.; Sasaki T.; Mohammad S.; Hwang H.; Tomy E.; Somaa F.; Ishibashi N.; Okano H.; Rakic P.; Hashimoto-Torii K.; Torii M.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	The developing brain is under the risk of exposure to a multitude of environmental stressors. While perinatal exposure to excessive levels of environmental stress is responsible for a wide spectrum of neurological and psychiatric conditions, the developing brain is equipped with intrinsic cell protection, the mechanisms of which remain unknown. Here we show, using neonatal mouse as a model system, that primary cilia, hair-like protrusions from the neuronal cell body, play an essential role in protecting immature neurons from the negative impacts of exposure to environmental stress. More specifically, we found that primary cilia prevent the degeneration of dendritic arbors upon exposure to alcohol and ketamine, two major cell stressors, by activating cilia-localized insulin-like growth factor 1 receptor and downstream Akt signaling. We also found that activation of this pathway inhibits Caspase-3 activation and caspase-mediated cleavage/fragmentation of cytoskeletal proteins in stress-exposed neurons. These results indicate that primary cilia play an integral role in mitigating adverse impacts of environmental stressors such as drugs on perinatal brain development. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cortical neurons; Dendrite; Environmental stress; Ketamine; Primary cilia
语种	英语
scopus关键词	alcohol; caspase 3; cytoskeleton protein; ketamine; protein kinase B; somatomedin C receptor; Akt signaling; animal cell; animal experiment; animal model; animal tissue; Article; brain cell; brain cortex; brain development; cellular stress response; controlled study; dendrite; enzyme activation; forebrain; microglia; mouse; nerve cell degeneration; neuroprotection; newborn; nonhuman; perikaryon; primary cilium; priority journal; protein cleavage; pyramidal nerve cell
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181147
作者单位	Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC 20010, United States; Department of Physiology, Keio University School of Medicine, Tokyo, 160-8582, Japan; Institute of Biomedical Sciences, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, United States; Department of Neuroscience, School of Medicine, Yale University, New Haven, CT 06520-8001, United States; Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, United States
推荐引用方式 GB/T 7714	Ishii S.,Sasaki T.,Mohammad S.,et al. Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration[J],2021,118(1).
APA	Ishii S..,Sasaki T..,Mohammad S..,Hwang H..,Tomy E..,...&Torii M..(2021).Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Ishii S.,et al."Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).