气候变化领域集成服务门户(CCPortal): Environmental noise degrades hippocampus-related learning and memory

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DOI	10.1073/pnas.2017841117
	Environmental noise degrades hippocampus-related learning and memory
	Zhang Y.; Zhu M.; Sun Y.; Tang B.; Zhang G.; An P.; Cheng Y.; Shan Y.; Merzenich M.M.; Zhou X.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	The neural mechanisms underlying the impacts of noise on nonauditory function, particularly learning and memory, remain largely unknown. Here, we demonstrate that rats exposed postnatally (between postnatal days 9 and 56) to structured noise delivered at a sound pressure level of ∼65 dB displayed significantly degraded hippocampus-related learning and memory abilities. Noise exposure also suppressed the induction of hippocampal long-term potentiation (LTP). In parallel, the total or phosphorylated levels of certain LTP-related key signaling molecules in the synapses of the hippocampus were down-regulated. However, no significant changes in stress-related processes were found for the noise-exposed rats. These results in a rodent model indicate that even moderate-level noise with little effect on stress status can substantially impair hippocampus-related learning and memory by altering the plasticity of synaptic transmission. They support the importance of more thoroughly defining the unappreciated hazards of moderately loud noise in modern human environments. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Behavior; Hippocampus; Noise exposure; Plasticity; Rat
语种	英语
scopus关键词	animal experiment; animal model; article; hippocampus; human; learning; long term potentiation; male; memory; noise; nonhuman; rat; rodent model; signal transduction; sound pressure; stress; synaptic transmission
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181145
作者单位	Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China; New York University-East China Normal University, Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai, 200062, China; Brain Plasticity Institute, San Francisco, CA 94111, United States
推荐引用方式 GB/T 7714	Zhang Y.,Zhu M.,Sun Y.,et al. Environmental noise degrades hippocampus-related learning and memory[J],2021,118(1).
APA	Zhang Y..,Zhu M..,Sun Y..,Tang B..,Zhang G..,...&Zhou X..(2021).Environmental noise degrades hippocampus-related learning and memory.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Zhang Y.,et al."Environmental noise degrades hippocampus-related learning and memory".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).