气候变化领域集成服务门户(CCPortal): Filling the gaps in the global prevalence map of clinical antimicrobial resistance

CCPortal

DOI	10.1073/PNAS.2013515118
	Filling the gaps in the global prevalence map of clinical antimicrobial resistance
	Oldenkamp R.; Schultsz C.; Mancini E.; Cappuccio A.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Surveillance is critical in containing globally increasing antimicrobial resistance (AMR). Affordable methodologies to prioritize AMR surveillance efforts are urgently needed, especially in low- and middle-income countries (LMICs), where resources are limited. While socioeconomic characteristics correlate with clinical AMR prevalence, this correlation has not yet been used to estimate AMR prevalence in countries lacking surveillance. We captured the statistical relationship between AMR prevalence and socioeconomic characteristics in a suite of beta-binomial principal component regression models for nine pathogens resistant to 19 (classes of) antibiotics. Prevalence data from ResistanceMap were combined with socioeconomic profiles constructed from 5,595 World Bank indicators. Cross-validated models were used to estimate clinical AMR prevalence and temporal trends for countries lacking data. Our approach provides robust estimates of clinical AMR prevalence in LMICs for most priority pathogens (cross-validated q2 > 0.78 for six out of nine pathogens). By supplementing surveillance data, 87% of all countries worldwide, which represent 99% of the global population, are now informed. Depending on priority pathogen, our estimates benefit 2.1 to 4.9 billion people living in countries with currently insufficient diagnostic capacity. By estimating AMR prevalence worldwide, our approach allows for a data-driven prioritization of surveillance efforts. For carbapenem-resistant Acinetobacter baumannii and third-generation cephalosporin-resistant Escherichia coli, specific countries of interest are located in the Middle East, based on the magnitude of estimates; sub-Saharan Africa, based on the relative prevalence increase over 1998 to 2017; and the Pacific Islands, based on improving overall model coverage and performance. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Antimicrobial resistance; Carbapenem-resistant Acinetobacter baumannii; Global health; Surveillance; Third-generation cephalosporin-resistant Escherichia coli
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181119
作者单位	Amsterdam Institute for Global Health and Development, Amsterdam, 1105 BP, Netherlands; Department of Global Health, Amsterdam University Medical Centres, Location AMC, Amsterdam, 1105 AZ, Netherlands; Institute of Life Sciences and Technologies, Daugavpils University, Daugavpils, LV-5401, Latvia; Institute for Advanced Study, University of Amsterdam, Amsterdam, 1012 GC, Netherlands; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
推荐引用方式 GB/T 7714	Oldenkamp R.,Schultsz C.,Mancini E.,et al. Filling the gaps in the global prevalence map of clinical antimicrobial resistance[J],2021,118(1).
APA	Oldenkamp R.,Schultsz C.,Mancini E.,&Cappuccio A..(2021).Filling the gaps in the global prevalence map of clinical antimicrobial resistance.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Oldenkamp R.,et al."Filling the gaps in the global prevalence map of clinical antimicrobial resistance".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).